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Abstract
This Podcast features a conversation with authors of a Research Article published in the 31 January 2012 issue of Science Signaling. Jared Rutter and Caleb Cardon discuss their discovery that signaling through PAS kinases can bypass signaling through Tor2 in yeast. Tor2 is one of two Tor kinases that participate in signaling through the yeast target of rapamycin (TOR) pathway, which integrates information about cellular nutrient and energy status to control growth. Cells lacking Tor2 cannot grow, but activation of either of two PAS kinases can restore growth to Tor2-deficient cells by activating a downstream target of Tor2 signaling. The authors demonstrate that PAS kinases are part of a protein complex that may integrate metabolic and stress signaling.
