07 February 2012
Vol 5, Issue 210
  • Contents

    • Research Articles

    • Perspective

    • Podcast

    • Editors' Choice

      • Starting a Beneficial Path

        Resveratrol acts as a competitive phosphodiesterase inhibitor to initiate pathways that mediate its beneficial effects on metabolic disorders.

      • Immune Sentinels

        A specialized population of B lymphocytes is important for controlling bacterial infections and preventing sepsis.

      • Polyfunctional T Cells

        Temporal analysis of individual activated T cells reveals programs of sequential secretion of multiple effector cytokines.

      • To Be or Not to Be

        By altering the transcriptional response to Notch signaling, the transcription factor Hamlet enables Notch to specify diverse cell fates.

      • Pairing Up for Patterning

        Biochemistry and genetics reveal the identity of specific ligand-receptor pairs that affect stomatal development.

      • Separated in Time and Space

        Sequential interactions of Notch and Wnt signaling are required for segregation of mesoderm and endoderm in the sea urchin embryo.

      • Natural Resistance

        Resistance to avermectin, an antinematode drug, is conferred by a deletion in a glutamate-gated chloride channel.

About The Cover

Cover image expansion

Online Cover This week features a Research Article on the regulated activation through phosphorylation of the zinc channel ZIP7, which triggers the release of zinc from the endoplasmic reticulum. The image shows MCF-7 cells overexpressing recombinant ZIP7, demonstrating endoplasmic reticulum mesh and perinuclear staining. [Image: Kathryn Taylor, Cardiff University, Wales, UK]