PTEN Directly Activates the Actin Depolymerization Factor Cofilin-1 During PGE2-Mediated Inhibition of Phagocytosis of Fungi

C. Henrique Serezani; Steve Kane; Alexandra I. Medeiros; Ashley M. Cornett; Sang-Hoon Kim; Mariana Morato Marques; Sang-Pyo Lee; Casey Lewis; Emilie Bourdonnay; Megan N. Ballinger; Eric S. White; Marc Peters-Golden

doi:10.1126/scisignal.2002448

Research ArticleHost-Pathogen Interactions

PTEN Directly Activates the Actin Depolymerization Factor Cofilin-1 During PGE₂-Mediated Inhibition of Phagocytosis of Fungi

C. Henrique Serezani¹,
Steve Kane¹,
Alexandra I. Medeiros²,
Ashley M. Cornett¹,
Sang-Hoon Kim³,
Mariana Morato Marques⁴,
Sang-Pyo Lee⁵,
Casey Lewis¹,
Emilie Bourdonnay¹,
Megan N. Ballinger¹,
Eric S. White¹, and
Marc Peters-Golden¹,*

¹Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA.
²Department of Biological Sciences, School of Pharmaceutical Sciences, São Paulo State University–UNESP, Araraquara 14801-902, Brazil.
³Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Eulji University School of Medicine, Seoul 139-711, South Korea.
⁴Department of Immunology, Institute of Biomedical Science IV, University of São Paulo, São Paulo 05508-000, Brazil.
⁵Division of Allergy, Gachon University Gil Hospital, Incheon 405-760, South Korea.

↵*To whom correspondence should be addressed. E-mail: petersm{at}umich.edu

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Science Signaling 07 Feb 2012:
Vol. 5, Issue 210, pp. ra12
DOI: 10.1126/scisignal.2002448

C. Henrique Serezani

1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA.

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Steve Kane

1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA.

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Alexandra I. Medeiros

2Department of Biological Sciences, School of Pharmaceutical Sciences, São Paulo State University–UNESP, Araraquara 14801-902, Brazil.

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Ashley M. Cornett

1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA.

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Sang-Hoon Kim

3Division of Allergy and Respiratory Medicine, Department of Internal Medicine, Eulji University School of Medicine, Seoul 139-711, South Korea.

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Mariana Morato Marques

4Department of Immunology, Institute of Biomedical Science IV, University of São Paulo, São Paulo 05508-000, Brazil.

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Sang-Pyo Lee

5Division of Allergy, Gachon University Gil Hospital, Incheon 405-760, South Korea.

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Casey Lewis

1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA.

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Emilie Bourdonnay

1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA.

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Megan N. Ballinger

1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA.

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Eric S. White

1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA.

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Marc Peters-Golden

1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA.

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For correspondence: petersm@umich.edu

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PTEN Directly Activates the Actin Depolymerization Factor Cofilin-1 During PGE₂-Mediated Inhibition of Phagocytosis of Fungi

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