Contents
Vol 5, Issue 211
Contents
Research Articles
- Selective TRIF-Dependent Signaling by a Synthetic Toll-Like Receptor 4 Agonist
A single change in a synthetic lipid A mimetic may reduce the toxicity of this vaccine adjuvant.
- MNK2 Inhibits eIF4G Activation Through a Pathway Involving Serine-Arginine–Rich Protein Kinase in Skeletal Muscle
In muscle, the kinase-dependent and -independent functions of MNK2 inhibit the protein translation protein eIF4G under conditions that promote atrophy.
Teaching Resource
- Measurement of cAMP in an Undergraduate Teaching Laboratory, Using ALPHAscreen Technology
Students measure the changes in cyclic AMP, a second messenger molecule, with a light-based assay.
Podcast
- Science Signaling Podcast: 14 February 2012
The protein phosphatase activity of PTEN impairs macrophage phagocytosis of a fungal pathogen by promoting actin depolymerization.
Editors' Choice
- Keeping a Kinase in Check
Details are revealed as to how cyclic adenosine monophosphate (cAMP) binding causes dissociation and activation of cAMP-dependent protein kinase.
- A Coincidence Detector with a Memory
The transcription factor NFAT converts a short calcium signal into a long-term, all-or-none gene expression response.
- Maintaining Equilibrium
The arrangement of four central ion-binding sites with differing specificities suggests how a membrane transporter protein works.
- Challenging the Mushroom Bodies
Protein synthesis underlying olfactory memory storage takes place outside the mushroom body—the site of memory storage.
- Too Much Tolerance?
Maintenance of T cell tolerance is likely regulated by epigenetic mechanisms.
- Screening for Interactions
An RNAi-based screen reveals that the energy-sensing protein AMPK is acetylated by p300 and deacetylated by HDAC1.
- Have You Heard About Levitra?
The type 5 phosphodiesterase inhibitor Levitra (vardenafil) prevents noise-induced hearing loss in rats.
