Contents
Vol 5, Issue 212
Contents
Research Articles
- RGS Proteins Maintain Robustness of GPCR-GIRK Coupling by Selective Stimulation of the G Protein Subunit Gαo
Opposing actions of RGS proteins both stimulate and inhibit G proteins to modulate the amplitude and kinetics of the downstream response.
- Inhibition of Autophagy Ameliorates Acute Lung Injury Caused by Avian Influenza A H5N1 Infection
Blocking autophagy reduces the extent of lung damage and decreases mortality in mice infected with the H5N1 strain of avian influenza.
Perspective
- Semaphorin Signaling Meets Rap
Semaphorin binding stimulates the ability of plexin receptors to inhibit the GTPase Rap1, thereby enabling neurite retraction.
Presentation
- TGF-β Signaling in Endothelial-to-Mesenchymal Transition: The Role of Shear Stress and Primary Cilia
The loss of primary cilia is a prerequisite for flow-induced endothelial-to-mesenchymal transition in heart development.
Editors' Choice
- Sweet Signals
The exposure of host sugar molecules from damaged intracellular vesicles containing bacteria stimulates an autophagic response to combat infection.
- LRP2 Gives Patched a Hand
The receptor LRP2 appears to deliver the morphogen Sonic hedgehog to its receptor Patched to enable proper specification of the ventral forebrain.
- Adapting to the Cold
Octopus potassium channels function efficiently at different temperatures due to RNA editing and not genetic differences.
- The PKA Swarm
Inhibiting protein kinase A in locusts attenuates the acquisition of gregarious behavior, which is required for swarming.
- Targeting Ubiquitination with PARylation
Poly(ADP-ribosyl)ation may recruit ubiquitin E3 ligases to target proteins.
- A Lipid Sensing GPCR
A channel in a lipid-dependent GPCR allows ligand to access its binding site from within the plasma membrane.
- Limiting Notch Signaling with Akt
Without PTEN to restrain Akt activity, Notch signaling is inhibited and neural progenitor cells become depleted.
- From NO to Complement
Expression of nitric oxide synthase followed by peroxidase activity makes Plasmodium visible to the insect’s complement system.
- Flagellin Takes Its Toll
Bacterially derived flagellin binds to an innate immune receptor to form a tail-to-tail heterodimeric signaling complex.
- Nanorobots Deliver
Cargoes stored in folded DNA origami are released when aptamers in the structure bind target protein molecules.
Erratum
- A Correction to the Perspective Titled: “Is the Regulation of Insulin Signaling Multi-Organismal?” by A. E. Douglas
Two misleading or scientifically inaccurate statements were made, one in the abstract and one in the main text.
