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Research ArticleCancer
Akt and ERK Control the Proliferative Response of Mammary Epithelial Cells to the Growth Factors IGF-1 and EGF Through the Cell Cycle Inhibitor p57Kip2
- Devin T. Worster1,
- Tobias Schmelzle1,*,
- Nicole L. Solimini1,†,
- Eric S. Lightcap2,
- Bjorn Millard3,
- Gordon B. Mills4,
- Joan S. Brugge1,‡, and
- John G. Albeck1
- 1Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
- 2Millennium Pharmaceuticals, Cambridge, MA 02139, USA.
- 3Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
- 4Department of Systems Biology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.
- ↵‡To whom correspondence should be addressed. E-mail: joan_brugge{at}hms.harvard.edu
See allHide authors and affiliations
Science Signaling 06 Mar 2012:
Vol. 5, Issue 214, pp. ra19
DOI: 10.1126/scisignal.2001986
Vol. 5, Issue 214, pp. ra19
DOI: 10.1126/scisignal.2001986
Devin T. Worster
1Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Tobias Schmelzle
1Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Nicole L. Solimini
1Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Eric S. Lightcap
2Millennium Pharmaceuticals, Cambridge, MA 02139, USA.
Bjorn Millard
3Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
Gordon B. Mills
4Department of Systems Biology, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.
Joan S. Brugge
1Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
John G. Albeck
1Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
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