Contents
Vol 5, Issue 215
Contents
Research Article
- Regulation of the EGF Transcriptional Response by Endocytic Sorting
The transcriptional response to EGFR activation is rapidly initiated after receptor stimulation before degradative sorting occurs.
Research Resource
- Proteome-Wide Discovery of Evolutionary Conserved Sequences in Disordered Regions
A statistical analysis method can identify short, functionally important linear motifs in disordered regions of proteins.
Perspective
- From Sulfenylation to Sulfhydration: What a Thiolate Needs to Tolerate
New techniques have revealed the dynamics of posttranslational modifications triggered by redox signaling that target cysteine residues.
Editors' Choice
- Sphingolipids Lower the Death Threshold
Sphingolipids from other organellar membranes set the threshold for mitochondrial permeabilization leading to cell death.
- Smoke Signals
Closely related hydrolases allow plants to distinguish between chemically similar compounds that elicit distinct physiological responses.
- Akting to Derepress Interferon Responses
The kinase Akt1 specifically enhances type I interferon responses by relieving the repression of interferon-stimulated genes.
- Making Immune Cells Young Again
The RNA binding protein Lin28 drives fetal modes of immune cell development.
- Neurogenesis and Pattern Integration
A specific set of functional properties can be attributed to immature granule cells developing in the hippocampus.
- Kibra Is a Pez Dispenser
The FERM domain protein Pez is required for Hippo signaling to restrict stem cell proliferation in the fly gut.
Erratum
- A Correction to the Research Article Titled: “Plexins Are GTPase-Activating Proteins for Rap and Are Activated by Induced Dimerization” by Y. Wang, H. He, N. Srivastava, S. Vikarunnessa, Y.-b. Chen, J. Jiang, C. W. Cowan, X. Zhang
The authors correct a sequence range in the Materials and Methods section.
