Contents
Vol 5, Issue 216
Contents
Research Articles
- Cellular Inhibitors of Apoptosis Are Global Regulators of NF-κB and MAPK Activation by Members of the TNF Family of Receptors
Signaling downstream of tumor necrosis factor family receptors hinges on the presence or absence of c-IAP proteins.
- Cannabinoids Induce Pancreatic β-Cell Death by Directly Inhibiting Insulin Receptor Activation
Activation of cannabinoid 1 receptors prevents insulin receptors from promoting β-cell survival in the pancreas.
Perspective
- The Structure of the TLR5-Flagellin Complex: A New Mode of Pathogen Detection, Conserved Receptor Dimerization for Signaling
TLR5 exhibits a distinct ligand-binding mechanism compared with those used by other TLRs.
Editors' Choice
- PKM2 Moonlights as a Protein Kinase
Pyruvate kinase M2 phosphorylates the transcription factor STAT3.
- Unexpected Akt-ions
The kinase Akt and the transcription factor Foxo1 may not be required for hepatic responses to insulin.
- Anticancer Glycyl-tRNA Synthetase from the Outside
Glycyl-tRNA synthetase released from macrophages promotes tumor cell death.
- Copper as a Kinase Cofactor
Copper promotes MAPK signaling by enhancing MEK-mediated phosphorylation of ERK.
- Sensing and Regulating Fat?
Presence of variant form of the lipid-sensing G protein–coupled receptor GPR120 with impaired function is associated with obesity.
- Making Carlactone
Elucidation of the biosynthetic pathway of a new plant hormone variant that may be useful in agricultural settings is shown.
- Facilitating Fusion and Release
Whereas one fusion protein complex can fuse a vesicle with a bilayer, three are needed for efficient content release.
- A Synaptic Vesicle in Time
Tracking of individual synaptic vesicles reveals that kiss-and-run fusion is concentrated near the center of the synapse.
- Toward Addiction
In laboratory experiments, male fruit flies respond to lack of sex by increasing alcohol consumption.
- Telling Sandpaper from Satin
A mutation known to cause cataracts also disables a specialized mechanosensory receptor in mice and humans.
