Editors' ChoiceNeuroscience

A Synaptic Vesicle in Time

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Science Signaling  20 Mar 2012:
Vol. 5, Issue 216, pp. ec88
DOI: 10.1126/scisignal.2003050

Synaptic vesicles move extensively within presynaptic nerve terminals, and their positional features are thought to have an impact on the likelihood and mode of vesicle fusion and transmitter release. Park et al. now provide real-time, three-dimensional tracking of individual synaptic vesicles in living nerve terminals. Single synaptic vesicles were identified within hippocampal neurons right up to the moment of exocytosis.

H. Park, Y. Li, R. W. Tsien, Influence of synaptic vesicle position on release probability and exocytotic fusion mode. Science 335, 1362–1366 (2012). [Abstract] [Full Text]

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