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Abstract
This Podcast features a conversation with the author of Research Articles published in the 14 February 2012 and 29 November 2011 issues of Science Signaling. David Glass discusses how protein synthesis is regulated in muscles in the contexts of both hypertrophy and atrophy. The changes in muscle mass that characterize hypertrophy and atrophy are caused by changes in protein production and degradation rather than changes in cell number. Research by Glass’s group has demonstrated that signaling through the G protein Gαi2 promotes hypertrophy and regeneration and inhibits atrophy. They also found that the kinase MNK2 promotes atrophy by inhibiting protein translation through two mechanisms, one of which involves the target of rapamycin (TOR) pathway.
