Contents
Vol 5, Issue 219
Contents
Research Articles
- Direct Binding Between Orai1 and AC8 Mediates Dynamic Interplay Between Ca2+ and cAMP Signaling
A signaling complex enables the compartmentalized regulation of cyclic AMP signaling by calcium entering through a specific channel.
- Ras Stabilization Through Aberrant Activation of Wnt/β-Catenin Signaling Promotes Intestinal Tumorigenesis
Crosstalk between the Wnt/β-catenin and the MAPK pathways contributes to colon cancer.
Perspective
- Wnt/β-Catenin and MAPK Signaling: Allies and Enemies in Different Battlefields
The crosstalk between two signaling pathways can be either pro- or anti-oncogenic, depending on the type of cancer.
Podcast
- Science Signaling Podcast: 10 April 2012
New findings elucidate mechanisms by which astrocytes can modulate neuronal activity.
Editors' Choice
- Better to Be Young at Heart?
Changes in glycosaminoglycan abundance and function are associated with altered growth factor signaling in aged heart muscle.
- Mitochondria, Apoptosis, and the Inflammasome
Oxidized DNA released from damaged mitochondria directly activates the NLRP3 inflammasome to stimulate inflammation.
- IL-22 Protects the Thymus
Damage to the thymus caused by infection or radiation is reversed by a cytokine.
- Tic TOC1 Plant Clock
Morning and evening components of circadian rhythms are coordinated and stabilized by a repressor.