Contents

Contents

• Research Articles

  • Direct Binding Between Orai1 and AC8 Mediates Dynamic Interplay Between Ca²⁺ and cAMP Signaling

    By Debbie Willoughby, Katy L. Everett, Michelle L. Halls, Jonathan Pacheco, Philipp Skroblin, Luis Vaca, Enno Klussmann, Dermot M. F. Cooper

    Sci. Signal.10 Apr 2012 : ra29 Full AccessRestricted Access

    A signaling complex enables the compartmentalized regulation of cyclic AMP signaling by calcium entering through a specific channel.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

  • Ras Stabilization Through Aberrant Activation of Wnt/β-Catenin Signaling Promotes Intestinal Tumorigenesis

    By Woo-Jeong Jeong, Juyong Yoon, Jong-Chan Park, Soung-Hoon Lee, Seung-Hoon Lee, Saluja Kaduwal, Hoguen Kim, Jong-Bok Yoon, Kang-Yell Choi

    Sci. Signal.10 Apr 2012 : ra30 Full AccessRestricted Access

    Crosstalk between the Wnt/β-catenin and the MAPK pathways contributes to colon cancer.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

• Perspective

  • Wnt/β-Catenin and MAPK Signaling: Allies and Enemies in Different Battlefields

    By Daniele Guardavaccaro, Hans Clevers

    Sci. Signal.10 Apr 2012 : pe15 Full AccessRestricted Access

    The crosstalk between two signaling pathways can be either pro- or anti-oncogenic, depending on the type of cancer.

    • Abstract
    • Full Text
    • PDF

• Podcast

  • Science Signaling Podcast: 10 April 2012

    By Maiken Nedergaard, Katsuhiko Mikoshiba, Annalisa M. VanHook

    Sci. Signal.10 Apr 2012 : pc8 Full AccessRestricted Access

    New findings elucidate mechanisms by which astrocytes can modulate neuronal activity.

    • Abstract
    • Full Text

• Editors' Choice

  • Break a Bone

    By Wei Wong

    Sci. Signal.10 Apr 2012 : ec104 Full AccessRestricted Access

    Vitamin E supplementation may cause decreased bone mass.

    • Abstract

  • Better to Be Young at Heart?

    By Annalisa M. VanHook

    Sci. Signal.10 Apr 2012 : ec105 Full AccessRestricted Access

    Changes in glycosaminoglycan abundance and function are associated with altered growth factor signaling in aged heart muscle.

    • Abstract

  • Mitochondria, Apoptosis, and the Inflammasome

    By John F. Foley

    Sci. Signal.10 Apr 2012 : ec106 Full AccessRestricted Access

    Oxidized DNA released from damaged mitochondria directly activates the NLRP3 inflammasome to stimulate inflammation.

    • Abstract

  • IL-22 Protects the Thymus

    By Kristen L. Mueller

    Sci. Signal.10 Apr 2012 : ec107 Full AccessRestricted Access

    Damage to the thymus caused by infection or radiation is reversed by a cytokine.

    • Abstract

  • Tic TOC1 Plant Clock

    By Pamela J. Hines

    Sci. Signal.10 Apr 2012 : ec108 Full AccessRestricted Access

    Morning and evening components of circadian rhythms are coordinated and stabilized by a repressor.

    • Abstract