Research ArticleCompartmentalized Signaling

Direct Binding Between Orai1 and AC8 Mediates Dynamic Interplay Between Ca2+ and cAMP Signaling

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Science Signaling  10 Apr 2012:
Vol. 5, Issue 219, pp. ra29
DOI: 10.1126/scisignal.2002299

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  • Direct Binding Between Orai1 and AC8 Mediates Dynamic Interplay Between Ca2+ and cAMP Signaling

    By Debbie Willoughby, Katy L. Everett, Michelle L. Halls, Jonathan Pacheco, Philipp Skroblin, Luis Vaca, Enno Klussmann, Dermot M. F. Cooper

    Science Signaling : ra29

    A signaling complex enables the compartmentalized regulation of cyclic AMP signaling by calcium entering through a specific channel.

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