Contents
Vol 5, Issue 223
Contents
Editorial Guide
- Focus Issue: Series on Structural Biology
Research and commentary highlight the use of structural analysis to understand signaling molecules and events.
Research Articles
- Syndecan 4 Regulates FGFR1 Signaling in Endothelial Cells by Directing Macropinocytosis
Macropinocytosis controls the kinetics of endothelial signaling initiated by a fibroblast growth factor receptor.
- An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt
ATP and ATP-competitive inhibitors prevent dephosphorylation of the kinase Akt.
Perspective
- Uncaging Akt
ATP and ADP regulate a conformational switch that determines the kinase activity of Akt.
Podcast
- Science Signaling Podcast: 8 May 2012
Maximal blood vessel dilation can be induced by calcium influx through just a few channel molecules in vascular endothelial cells.
Editors' Choice
- Draper Doppelganger
A receptor that mediates engulfment of damaged neurons is inhibited by an alternatively spliced isoform.
- Three Dimensions, Two Modes of Migration
Elastic properties of the extracellular matrix and nonpolarized signaling govern how cells migrate in three-dimensional environments.
- Synchronizing Developmental Timing with Growth
A secreted insulin-like peptide couples developmental timing to organ growth in the fruit fly.
- Metabolic Networking
A key design principle of bacterial metabolic networks is optimal performance, but not at the expense of adaptability.
- Blood Pressure Gauge
Imaging reveals single-channel openings of cation channels at the heart of endothelial cell–mediated blood pressure control.
- Gene Expression by Remote Control
Gene expression in mice can be activated remotely and noninvasively by radio-wave heating of nanoparticles.
- Not Broken Until Repaired
“Naked” chromosome ends are mistakenly targeted by six different DNA repair–related systems in the cell.
Erratum
- A Correction to the Perspective Titled: “The Structure of the TLR5-Flagellin Complex: A New Mode of Pathogen Detection, Conserved Receptor Dimerization for Signaling” by J. Lu and P. D. Sun
The position of flagellin in the figure is corrected.
