Contents

Contents

• Research Article

  • Interferon-β Therapy Against EAE Is Effective Only When Development of the Disease Depends on the NLRP3 Inflammasome

    By Makoto Inoue, Kristi L. Williams, Timothy Oliver, Peter Vandenabeele, Jayant V. Rajan, Edward A. Miao, Mari L. Shinohara

    Sci. Signal.22 May 2012 : ra38 Full AccessRestricted Access

    Characterization of an animal model may explain why not all patients with multiple sclerosis respond to interferon-β.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

• Perspectives

  • Structure of the First Sphingosine 1-Phosphate Receptor

    By Abby L. Parrill, Santiago Lima, Sarah Spiegel

    Sci. Signal.22 May 2012 : pe23 Full AccessRestricted Access

    The lipid sphingosine 1-phosphate may laterally diffuse through the membrane to bind a receptor.

    • Abstract
    • Full Text
    • PDF

  • Revisiting Channel Allostery: A Coherent Mechanism in IP₃ and Ryanodine Receptors

    By Kozo Hamada, Katsuhiko Mikoshiba

    Sci. Signal.22 May 2012 : pe24 Full AccessRestricted Access

    Structural analyses suggest a similar gating mechanism in the IP₃ and ryanodine receptors.

    • Abstract
    • Full Text
    • PDF

• Podcast

  • Science Signaling Podcast: 22 May 2012

    By Mari L. Shinohara, Annalisa M. VanHook

    Sci. Signal.22 May 2012 : pc11 Full AccessRestricted Access

    Interferon-β therapy is only effective in treating a mouse model of multiple sclerosis when the disease is dependent upon the NLRP3 inflammasome.

    • Abstract
    • Full Text

• Editors' Choice

  • Keeping Neutrophils On Track

    By John F. Foley

    Sci. Signal.22 May 2012 : ec141 Full AccessRestricted Access

    Neutrophils following a gradient of primary chemoattractant secrete leukotriene B₄, generating a secondary gradient that enhances migration.

    • Abstract

  • Calpains Cleave and Activate TRPC5

    By Nancy R. Gough

    Sci. Signal.22 May 2012 : ec142 Full AccessRestricted Access

    Cleavage and activation of the cation channel TRPC5 by calpains may contribute to growth cone collapse.

    • Abstract

  • Color and Movement

    By Peter R. Stern

    Sci. Signal.22 May 2012 : ec143 Full AccessRestricted Access

    Fly photoreceptors that detect colors also contribute information to the processing of motion.

    • Abstract

  • Fat Remodeler

    By Wei Wong

    Sci. Signal.22 May 2012 : ec144 Full AccessRestricted Access

    Fibroblast growth factor 1A enables remodeling of adipose tissue in response to changes in diet.

    • Abstract

  • An Aspirin a Day?

    By L. Bryan Ray

    Sci. Signal.22 May 2012 : ec145 Full AccessRestricted Access

    A possible molecular mechanism of action for a metabolite of aspirin is described.

    • Abstract

  • Syndecan Teams Up with Notch

    By Ernesto Andrianantoandro

    Science Signaling22 May 2012 : ec146 Full AccessRestricted Access

    Syndecan-2 enhancement of Notch signaling in smooth muscle cells may play a role in angiogenesis.

    • Abstract

  • A Gatekeeper of Viral Entry

    By Ernesto Andrianantoandro

    Sci. Signal.22 May 2012 : ec147 Full AccessRestricted Access

    The receptor EphrinA2 promotes herpesvirus entry into endothelial cells.

    • Abstract