Contents
Vol 5, Issue 225
Contents
Research Article
- Interferon-β Therapy Against EAE Is Effective Only When Development of the Disease Depends on the NLRP3 Inflammasome
Characterization of an animal model may explain why not all patients with multiple sclerosis respond to interferon-β.
Perspectives
- Structure of the First Sphingosine 1-Phosphate Receptor
The lipid sphingosine 1-phosphate may laterally diffuse through the membrane to bind a receptor.
- Revisiting Channel Allostery: A Coherent Mechanism in IP3 and Ryanodine Receptors
Structural analyses suggest a similar gating mechanism in the IP3 and ryanodine receptors.
Podcast
- Science Signaling Podcast: 22 May 2012
Interferon-β therapy is only effective in treating a mouse model of multiple sclerosis when the disease is dependent upon the NLRP3 inflammasome.
Editors' Choice
- Keeping Neutrophils On Track
Neutrophils following a gradient of primary chemoattractant secrete leukotriene B4, generating a secondary gradient that enhances migration.
- Calpains Cleave and Activate TRPC5
Cleavage and activation of the cation channel TRPC5 by calpains may contribute to growth cone collapse.
- Color and Movement
Fly photoreceptors that detect colors also contribute information to the processing of motion.
- Fat Remodeler
Fibroblast growth factor 1A enables remodeling of adipose tissue in response to changes in diet.
- An Aspirin a Day?
A possible molecular mechanism of action for a metabolite of aspirin is described.
- Syndecan Teams Up with Notch
Syndecan-2 enhancement of Notch signaling in smooth muscle cells may play a role in angiogenesis.
- A Gatekeeper of Viral Entry
The receptor EphrinA2 promotes herpesvirus entry into endothelial cells.