Contents
Vol 5, Issue 226
Contents
Editorial Guide
- Focus Issue: Signaling Architecture from Domains to Complexes
Structural analyses of domains, proteins, and complexes provides insight into signaling mechanisms and uncovers therapeutic potential.
Research Article
- Sequence-Specific Recognition of a PxLPxI/L Motif by an Ankyrin Repeat Tumbler Lock
Phosphorylation of a motif that binds to ankyrin repeat domains switches its binding preference to 14-3-3 proteins.
Reviews
- Signal Activation and Inactivation by the Gα Helical Domain: A Long-Neglected Partner in G Protein Signaling
Structural studies suggest that the helical domain of G protein α subunits is an active participant in G protein signaling.
- Structural Insights into the Assembly of Large Oligomeric Signalosomes in the Toll-Like Receptor–Interleukin-1 Receptor Superfamily
Structural studies show that Toll-like receptors assemble into large oligomeric intracellular signaling complexes upon ligand binding.
Editors' Choice
- A BAD Metabolic Choice
Preventing the phosphorylation of BAD switches the primary fuel source of neurons from glucose to ketone bodies.
- Fighting Infection with Liposomes
Asymmetric engineered liposomes are antimicrobial and anti-inflammatory.
- Action at a Distance in Gene Expression
Tumor suppressor Nkx3.1 acts as an intercellular transcription factor.
- PERKing Up the ER Stress Response
PERK exhibits lipid kinase activity during the ER stress response and adipocyte differentiation.
- Spring Into Flower
A plant protein sensitive to blue light links longer afternoons to more flowering.
- Magnetic Sense
Neurons in a pigeon’s brain encode the direction and intensity of the geomagnetic field.
Erratum
- A Correction to the Perspective Titled: “Uncaging Akt” by S. J. Humphrey and D. E. James
A misstatement about the construct used in a highlighted paper is corrected.
