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vol. 5 no. 226 ra39
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- Received February 17, 2012
- Accepted May 10, 2012
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Copyright © 2012, American Association for the Advancement of Science
Research ArticleStructural Biology
Sequence-Specific Recognition of a PxLPxI/L Motif by an Ankyrin Repeat Tumbler Lock
- Chao Xu1,*,
- Jing Jin2,*,
- Chuanbing Bian1,
- Robert Lam1,†,
- Ruijun Tian2,
- Ryan Weist3,4,
- Linya You3,4,
- Jianyun Nie3,5,
- Alexey Bochkarev1,
- Wolfram Tempel1,
- Chris S. Tan2,
- Gregory A. Wasney1,
- Masoud Vedadi1,
- Gerald D. Gish2,
- Cheryl H. Arrowsmith1,6,
- Tony Pawson2,7,
- Xiang-Jiao Yang3,4, and
- Jinrong Min1,8,‡
- 1Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada.
- 2Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
- 3Rosalind and Morris Goodman Cancer Research Center and Department of Biochemistry, McGill University, Montréal, Québec H3A 1A3, Canada.
- 4Department of Medicine, McGill University Health Center, Montréal, Québec H3A 1A3, Canada.
- 5The Third Affiliated Hospital, Kunming Medical College, Yunnan 650031, China.
- 6Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada.
- 7Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
- 8Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
- ↵‡To whom correspondence should be addressed. E-mail: jr.min{at}utoronto.ca
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Science Signaling 29 May 2012:
Vol. 5, Issue 226, pp. ra39
DOI: 10.1126/scisignal.2002979
Vol. 5, Issue 226, pp. ra39
DOI: 10.1126/scisignal.2002979
Chao Xu
1Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada.
Jing Jin
2Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
Chuanbing Bian
1Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada.
Robert Lam
1Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada.
Ruijun Tian
2Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
Ryan Weist
3Rosalind and Morris Goodman Cancer Research Center and Department of Biochemistry, McGill University, Montréal, Québec H3A 1A3, Canada.
4Department of Medicine, McGill University Health Center, Montréal, Québec H3A 1A3, Canada.
Linya You
3Rosalind and Morris Goodman Cancer Research Center and Department of Biochemistry, McGill University, Montréal, Québec H3A 1A3, Canada.
4Department of Medicine, McGill University Health Center, Montréal, Québec H3A 1A3, Canada.
Jianyun Nie
3Rosalind and Morris Goodman Cancer Research Center and Department of Biochemistry, McGill University, Montréal, Québec H3A 1A3, Canada.
5The Third Affiliated Hospital, Kunming Medical College, Yunnan 650031, China.
Alexey Bochkarev
1Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada.
Wolfram Tempel
1Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada.
Chris S. Tan
2Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
Gregory A. Wasney
1Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada.
Masoud Vedadi
1Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada.
Gerald D. Gish
2Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
Cheryl H. Arrowsmith
1Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada.
6Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada.
Tony Pawson
2Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
7Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
Xiang-Jiao Yang
3Rosalind and Morris Goodman Cancer Research Center and Department of Biochemistry, McGill University, Montréal, Québec H3A 1A3, Canada.
4Department of Medicine, McGill University Health Center, Montréal, Québec H3A 1A3, Canada.
Jinrong Min
1Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada.
8Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
