Sequence-Specific Recognition of a PxLPxI/L Motif by an Ankyrin Repeat Tumbler Lock

Chao Xu; Jing Jin; Chuanbing Bian; Robert Lam; Ruijun Tian; Ryan Weist; Linya You; Jianyun Nie; Alexey Bochkarev; Wolfram Tempel; Chris S. Tan; Gregory A. Wasney; Masoud Vedadi; Gerald D. Gish; Cheryl H. Arrowsmith; Tony Pawson; Xiang-Jiao Yang; Jinrong Min

doi:10.1126/scisignal.2002979

Research ArticleStructural Biology

Sequence-Specific Recognition of a PxLPxI/L Motif by an Ankyrin Repeat Tumbler Lock

Chao Xu¹,*,
Jing Jin²,*,
Chuanbing Bian¹,
Robert Lam¹,†,
Ruijun Tian²,
Ryan Weist³,⁴,
Linya You³,⁴,
Jianyun Nie³,⁵,
Alexey Bochkarev¹,
Wolfram Tempel¹,
Chris S. Tan²,
Gregory A. Wasney¹,
Masoud Vedadi¹,
Gerald D. Gish²,
Cheryl H. Arrowsmith¹,⁶,
Tony Pawson²,⁷,
Xiang-Jiao Yang³,⁴, and
Jinrong Min¹,⁸,‡

¹Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada.
²Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.
³Rosalind and Morris Goodman Cancer Research Center and Department of Biochemistry, McGill University, Montréal, Québec H3A 1A3, Canada.
⁴Department of Medicine, McGill University Health Center, Montréal, Québec H3A 1A3, Canada.
⁵The Third Affiliated Hospital, Kunming Medical College, Yunnan 650031, China.
⁶Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada.
⁷Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
⁸Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

↵‡To whom correspondence should be addressed. E-mail: jr.min{at}utoronto.ca

↵* These authors contributed equally to this work.
↵† Present address: Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, 610 University Avenue, Toronto, Ontario M5G 2M9, Canada.

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Science Signaling 29 May 2012:
Vol. 5, Issue 226, pp. ra39
DOI: 10.1126/scisignal.2002979

Chao Xu

Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada.

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Jing Jin

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.

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Chuanbing Bian

Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada.

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Robert Lam

Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada.

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Ruijun Tian

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.

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Ryan Weist

Rosalind and Morris Goodman Cancer Research Center and Department of Biochemistry, McGill University, Montréal, Québec H3A 1A3, Canada.Department of Medicine, McGill University Health Center, Montréal, Québec H3A 1A3, Canada.

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Linya You

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Jianyun Nie

Rosalind and Morris Goodman Cancer Research Center and Department of Biochemistry, McGill University, Montréal, Québec H3A 1A3, Canada.The Third Affiliated Hospital, Kunming Medical College, Yunnan 650031, China.

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Alexey Bochkarev

Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada.

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Wolfram Tempel

Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada.

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Chris S. Tan

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.

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Gregory A. Wasney

Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada.

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Masoud Vedadi

Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada.

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Gerald D. Gish

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.

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Cheryl H. Arrowsmith

Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada.Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada.

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Tony Pawson

Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada.Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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Xiang-Jiao Yang

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Jinrong Min

Structural Genomics Consortium, University of Toronto, 101 College Street, Toronto, Ontario M5G 1L7, Canada.Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

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For correspondence: jr.min@utoronto.ca

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Sequence-Specific Recognition of a PxLPxI/L Motif by an Ankyrin Repeat Tumbler Lock

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