Contents
Vol 5, Issue 227
Contents
Research Articles
- Coupled Activation and Degradation of eEF2K Regulates Protein Synthesis in Response to Genotoxic Stress
DNA damage triggers the phosphorylation of factors involved in protein synthesis to regulate polypeptide elongation.
- Matrix Rigidity Controls Endothelial Differentiation and Morphogenesis of Cardiac Precursors
Culturing cardiac precursors on a surface with the rigidity of heart tissue increases the yield of endothelial cells.
Perspective
- F-Box Proteins Elongate Translation During Stress Recovery
An inhibitor of protein synthesis is activated by DNA damage and degraded during recovery.
Protocol
- Labeling and Identification of Direct Kinase Substrates
A strategy that uses analog-sensitive kinases enables the identification of low-abundance kinase substrates.
Editors' Choice
- Neurotoxic MicroRNA
Extracellular let-7 microRNA activates the innate immune receptor TLR7, triggering neuronal death.
- The Real McCoy
The elusive enzyme that modifies proteins involved in building bone and teeth has now been identified.
- The NADPH Survival Advantage
Under conditions of metabolic stress, tumor cells receive a survival advantage through AMPK-dependent maintenance of NADPH abundance.
- So Selective
Restricted B cell signaling in the areas responsible for immune memory cell production promotes affinity maturation.
- Dissecting Chitin Binding
Structural analysis shows how fungus-derived chitin dimerizes its receptor on target plants and triggers defense responses.
- Perturbing Behavior to Uncover Polarization Signals
Perturbation analysis reveals evolving connections between nodes in signaling networks underlying neutrophil polarization.
- Insights into Amyloidogenesis
The structure of the amyloid precursor protein transmembrane domain allows processive cleavage and cholesterol binding that may enhance cleavage.
