Contents
Vol 5, Issue 228
Contents
Research Articles
- The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis
The nuclear translocation of a transcription factor that promotes lysosomal biogenesis is inhibited when lysosomal function is adequate.
- The lin-4 MicroRNA Targets the LIN-14 Transcription Factor to Inhibit Netrin-Mediated Axon Attraction
A microRNA instructs neurons when to stop axonal pathfinding.
Perspective
- S-Nitrosylation Signaling in Escherichia coli
Bacteria respond to nitric oxide and oxygen in their environment using two different posttranslational modifications of the same transcription factor to promote expression of protective genes specific to each gas.
Podcast
- Science Signaling Podcast: 12 June 2012
Regulated nuclear translocation of a transcription factor maintains lysosomal homeostasis.
Editors' Choice
- TRADD: Promoting Senescence from Within the Nucleus
The adaptor protein TRADD acts as a tumor suppressor by blocking a specific nuclear ubiquitylation event.
- Complement Is Bad for Aging
Aging-associated increases in complement C1q activate the Wnt pathway and compromise tissue regeneration.
- Two Gases Required for Vasodilation and Angiogenesis
Nitric oxide and hydrogen sulfide signaling converge to promote cGMP-dependent processes in endothelial cells.
- Evading a Block on Translation
A complex containing HIF-2α enables the translation of select mRNAs under hypoxic conditions when most protein synthesis is normally inhibited.
- Keeping Baby Safe
Turning off the expression in the placenta of T cell attractants allows the mother to tolerate the fetus.
- The Mycobiome
Mammals contain resident fungal intestinal populations that influence disease susceptibility.
- Protecting Against a Barrier Breach
Lymphocytes prevent bacteria from spreading beyond gut-associated lymphoid tissues and causing systemic inflammation.
