Contents
Vol 5, Issue 229
Contents
Research Articles
- Direct Modification and Activation of a Nuclear Receptor–PIP2 Complex by the Inositol Lipid Kinase IPMK
The transcriptional activity of a nuclear receptor is regulated by the phosphorylation status of a bound lipid.
- Histone Deacetylases 6 and 9 and Sirtuin-1 Control Foxp3+ Regulatory T Cell Function Through Shared and Isoform-Specific Mechanisms
Combined inhibition of distinct histone deacetylases enhances the suppressive effects of regulatory T cells.
Perspective
- How Growth Abnormalities Delay “Puberty” in Drosophila
An insulin-like peptide delays metamorphosis of the fruit fly in response to injury or tissue overgrowth.
Podcast
- Science Signaling Podcast: 19 June 2012
Modification of a bound lipid modulates the activity of a nuclear receptor.
Editors' Choice
- How Smoking Leads to Aneurysms
Nicotine activates AMPK-α2, leading to abdominal aortic aneurysms in mice.
- Message in an Exosome
Melanomas transfer various proteins, including the receptor MET, to bone marrow–derived cells through exosomes to promote metastasis.
- Life and Death with Salicylic Acid
Two receptors for the plant hormone salicylic acid differentially determine cellular responses to infection.
- Channeling Death
Caspase-mediated cleavage of the channel TRPM7 enhances its activity and promotes Fas-mediated cell death.
- Dynamic Responses
After DNA damage, pulses of p53 allow recovery, whereas sustained levels lead to senescence.
