Contents
Vol 5, Issue 230
Contents
Research Article
- Selective Effects of PD-1 on Akt and Ras Pathways Regulate Molecular Components of the Cell Cycle and Inhibit T Cell Proliferation
The inhibitory receptor PD-1 blocks T cell proliferation by preventing cells from leaving the G1 phase of the cell cycle.
Perspective
- How Plant Lysin Motif Receptors Get Activated: Lessons Learned from Structural Biology
A plant immune receptor is selectively activated by larger chitin fragments that trigger receptor dimerization.
Podcast
- Science Signaling Podcast: 26 June 2012
An inhibitory receptor blocks proliferation of autoreactive T cells to promote tolerance in the periphery.
Editors' Choice
- Wnt Preserves Telomeres
Wnt signaling through β-catenin promotes genetic stability by stimulating the production of telomerase.
- RIGing the Antibacterial Response
Virus-induced activation of RIG-I–like receptors suppresses Toll-like receptor–dependent antibacterial responses.
- p53 Opens the Gates to Necrosis
p53 induces necrosis in response to oxidative stress by opening the mitochondrial permeability transition pore.
- Attract and Segregate
BMPs induce a series of signaling events that control migration and specification of sympathetic neurons and adrenal medullary cells from a progenitor population.
- Grb2: Adapting to Basal Activity
By binding to two receptor tyrosine kinase subunits, dimeric Grb2 may enable basal receptor phosphorylation, while limiting downstream signaling.
