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Abstract
This Podcast features an interview with Vassiliki Boussiotis, senior author of a Research Article published in the 26 June 2012 issue of Science Signaling. Boussiotis discusses her group’s investigation of a molecular mechanism by which autoreactive T cells are suppressed in the periphery. Most autoreactive T cells are eliminated by mechanisms of central tolerance in the bone marrow or thymus before they enter the circulation. Autoreactive T cells that escape central tolerance are suppressed or eliminated by mechanisms of peripheral tolerance. Boussiotis’s group has described a molecular chain of events downstream of the receptor programmed death-1 (PD-1) that inhibit proliferation of autoreactive T cells.
