Contents
Vol 5, Issue 231
Contents
Research Article
- Perinuclear Mitochondrial Clustering Creates an Oxidant-Rich Nuclear Domain Required for Hypoxia-Induced Transcription
Reactive oxygen species generated by mitochondria that redistribute near the nucleus promote transcriptional responses to hypoxia.
Research Resource
- Quantitative Imaging of Epithelial Cell Scattering Identifies Specific Inhibitors of Cell Motility and Cell-Cell Dissociation
Imaging analysis tools identify drugs that inhibit different aspects of cell scattering, which occurs in cancer cells.
Perspective
- New Targets for Acetylation in Autophagy
Yeast and mammals use protein acetylation to promote the formation of the autophagosome.
Podcast
- Science Signaling Podcast: 3 July 2012
Structural analysis reveals how a Wnt binds to its receptor.
Editors' Choice
- Two for One in Iron Homeostasis
The Chlamydia protein YtgCR is cleaved to yield a metal permease and an iron-regulated transcriptional repressor.
- PINning a Tumor Suppressor
Prolyl isomerization reduces the abundance of the tumor suppressor Fbw7 by triggering its self-ubiquitination.
- Stable, But Transcriptionally Inactive
Phosphorylation-stimulated SUMOylation of the estrogen receptor β prevents receptor degradation but also reduces promoter binding.
- A Linchpin for Metabolism and Immunity
A metabolic regulator also modulates immune cells in fatty tissue.
- Plant Hormone Modulators
Crystal structures of plant GH3 proteins reveal how these enzymes accommodate jasmonates, auxins, and benzoates.
