Quantitative Imaging of Epithelial Cell Scattering Identifies Specific Inhibitors of Cell Motility and Cell-Cell Dissociation

Dinah Loerke; Quint le Duc; Iris Blonk; Andre Kerstens; Emma Spanjaard; Matthias Machacek; Gaudenz Danuser; Johan de Rooij

doi:10.1126/scisignal.2002677

Research ResourceCell Biology

Quantitative Imaging of Epithelial Cell Scattering Identifies Specific Inhibitors of Cell Motility and Cell-Cell Dissociation

Dinah Loerke¹,*,^†,
Quint le Duc²,*,
Iris Blonk²,
Andre Kerstens¹,^‡,
Emma Spanjaard²,
Matthias Machacek¹,^§,
Gaudenz Danuser¹,^¶^∥, and
Johan de Rooij¹,²,^∥

¹Department of Cell Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
²Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584 CT Utrecht, Netherlands.

↵∥To whom correspondence should be addressed. E-mail: j.derooij{at}hubrecht.eu (J.d.R.); Gaudenz_Danuser{at}hms.harvard.edu (G.D.)

↵* These authors contributed equally to this work.
↵† Present address: Department of Physics and Astronomy, University of Denver, 2112 East Wesley Avenue, Denver, CO 80208, USA.
↵‡ Present address: Penguin Computing Inc., 45800 Northport Loop West, Fremont, CA 94538, USA.
↵§ Present address: Novartis Pharma AG, Lichtstrasse 35, CH-4056 Basel, Switzerland.
↵¶ Present address: Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA.

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Science Signaling 03 Jul 2012:
Vol. 5, Issue 231, pp. rs5
DOI: 10.1126/scisignal.2002677

Dinah Loerke

1Department of Cell Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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Quint le Duc

2Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584 CT Utrecht, Netherlands.

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Iris Blonk

2Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584 CT Utrecht, Netherlands.

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Andre Kerstens

1Department of Cell Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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Emma Spanjaard

2Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584 CT Utrecht, Netherlands.

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Matthias Machacek

1Department of Cell Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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Gaudenz Danuser

1Department of Cell Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

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For correspondence: j.derooij@hubrecht.eu Gaudenz_Danuser@hms.harvard.edu

Johan de Rooij

1Department of Cell Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

2Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, 3584 CT Utrecht, Netherlands.

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For correspondence: j.derooij@hubrecht.eu Gaudenz_Danuser@hms.harvard.edu

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