Contents
Vol 5, Issue 234
Contents
Research Articles
- p53 Functions in Endothelial Cells to Prevent Radiation-Induced Myocardial Injury in Mice
Without the transcription factor p53 in cardiac endothelial cells, the heart is more susceptible to radiation-induced damage.
- Distinct Spatial and Molecular Features of Notch Pathway Assembly in Regulatory T Cells
A cytosolic function of Notch helps regulatory T cells survive.
Perspective
- Notch and the Survival of Regulatory T Cells: Location Is Everything!
Cytosolic localization of Notch protects regulatory but not effector T cells from apoptosis caused by cytokine withdrawal.
Podcast
- Science Signaling Podcast: 24 July 2012
A transcription factor protects the heart from radiation-induced damage.
Editors' Choice
- Connecting Stress to Viral Reactivation
Local axonal signaling through mTORC1 maintains herpes virus latency in neurons.
- Opioid Receptor Satiety Signal
In nerves of the portal vein, antagonism of μ-opioid receptors by peptide products of digestion signals the brain to reduce food intake.
- SHARP1 Keeps Breast Cancer Cells from Metastasizing
SHARP1 mediates ubiquitin-independent targeting of hypoxia-inducible factors to the proteasome, thus reducing breast cancer metastasis.
- Redox Status Incites Gametogenesis
Maize anthers use cellular redox status rather than a specific germ cell lineage to signal production of new germ cells.
- Finding Another Role for NEMO
The adaptor protein NEMO, which is required for activation of the kinase IKKβ, also controls its specificity to ensure NF-κB activation.
