Contents
Vol 5, Issue 235
Contents
Editorial Guide
- Focus Issue: Regulation of Lymphocyte Function
Similar modes of regulation across different cell types promote effective innate and adaptive immunity.
Research Articles
- The Scaffolding Protein Synapse-Associated Protein 97 Is Required for Enhanced Signaling Through Isotype-Switched IgG Memory B Cell Receptors
A scaffolding protein clusters B cell receptors to enable the rapid, high-titer antibody responses of memory B cells.
- Differential RET Signaling Pathways Drive Development of the Enteric Lymphoid and Nervous Systems
Cis and trans signaling mechanisms direct different developmental responses to ligands for the receptor tyrosine kinase RET.
Perspectives
- T Cell Signaling Targets for Enhancing Regulatory or Effector Function
The PD-1 receptor in effector T cells and the transcription factor Foxp3 in Tregs are promising targets for therapies.
- Tyrosine Kinases EnAbling Adaptor Molecules for Chemokine-Induced Rap1 Activation in T Cells
T cell migration requires phosphorylation of an adaptor protein by Abl family kinases to activate guanosine triphosphatase Rap1.
Podcast
- Science Signaling Podcast: 31 July 2012
A scaffolding protein enables clustering of IgG B cell receptors to promote antibody secretion by memory B cells.
Editors' Choice
- Redundantly Resistant to Therapy
Stromal cells produce factors that help cancer cells resist chemotherapy treatment.
- Clearing Away Injured Axons
The adaptor protein Sarm1 is required for Wallerian degeneration of damaged axons.
- Anchors Away
Monomeric Homer isoforms release receptors from multimeric Homer scaffolds to mediate synaptic modulation.
- Membrane Fusion Stimulates STING
Fusion of a virus with the host cell membrane acts as a danger signal to trigger an antiviral response dependent on the adaptor STING.
- Tricky Tryps
Parasites release cyclic adenosine monophosphate when swallowed up by myeloid cells, thereby turning off a host defense pathway.
- Netting the Bad Guys
Rather than killing bacteria directly, a gut antimicrobial peptide forms netlike structures that ensnare invading bacteria.
