Contents

Contents

• Editorial Guide

  • Focus Issue: Regulation of Lymphocyte Function

    By Ernesto Andrianantoandro, John F. Foley

    Science Signaling31 Jul 2012 : eg8 Full AccessRestricted Access

    Similar modes of regulation across different cell types promote effective innate and adaptive immunity.

    • Abstract
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• Research Articles

  • The Scaffolding Protein Synapse-Associated Protein 97 Is Required for Enhanced Signaling Through Isotype-Switched IgG Memory B Cell Receptors

    By Wanli Liu, Elizabeth Chen, Xing Wang Zhao, Zheng Peng Wan, Yi Ren Gao, Angel Davey, Eric Huang, Lijia Zhang, Jillian Crocetti, Gabriel Sandoval, M. Gordon Joyce, Carrie Miceli, Jan Lukszo, L. Aravind, Wojciech Swat, Joseph Brzostowski, Susan K. Pierce

    Science Signaling31 Jul 2012 : ra54 Full AccessRestricted Access

    A scaffolding protein clusters B cell receptors to enable the rapid, high-titer antibody responses of memory B cells.

    • Editor's Summary
    • Abstract
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  • Differential RET Signaling Pathways Drive Development of the Enteric Lymphoid and Nervous Systems

    By Amisha Patel, Nicola Harker, Lara Moreira-Santos, Manuela Ferreira, Kieran Alden, Jon Timmis, Katie Foster, Anna Garefalaki, Panayotis Pachnis, Paul Andrews, Hideki Enomoto, Jeffrey Milbrandt, Vassilis Pachnis, Mark C. Coles, Dimitris Kioussis, Henrique Veiga-Fernandes

    Science Signaling31 Jul 2012 : ra55 Full AccessRestricted Access

    Cis and trans signaling mechanisms direct different developmental responses to ligands for the receptor tyrosine kinase RET.

    • Editor's Summary
    • Abstract
    • Full Text
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• Perspectives

  • T Cell Signaling Targets for Enhancing Regulatory or Effector Function

    By Fan Pan, Huimin Fan, Zhongmin Liu, Shuiping Jiang

    Science Signaling31 Jul 2012 : pe32 Full AccessRestricted Access

    The PD-1 receptor in effector T cells and the transcription factor Foxp3 in T_regs are promising targets for therapies.

    • Abstract
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  • Tyrosine Kinases EnAbling Adaptor Molecules for Chemokine-Induced Rap1 Activation in T Cells

    By Laurent P. Malherbe, Demin Wang

    Science Signaling31 Jul 2012 : pe33 Full AccessRestricted Access

    T cell migration requires phosphorylation of an adaptor protein by Abl family kinases to activate guanosine triphosphatase Rap1.

    • Abstract
    • Full Text
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• Podcast

  • Science Signaling Podcast: 31 July 2012

    By Susan K. Pierce, Annalisa M. VanHook

    Science Signaling31 Jul 2012 : pc17 Full AccessRestricted Access

    A scaffolding protein enables clustering of IgG B cell receptors to promote antibody secretion by memory B cells.

    • Abstract
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• Editors' Choice

  • Redundantly Resistant to Therapy

    By Ernesto Andrianantoandro

    Science Signaling31 Jul 2012 : ec199 Full AccessRestricted Access

    Stromal cells produce factors that help cancer cells resist chemotherapy treatment.

    • Abstract

  • Clearing Away Injured Axons

    By Annalisa M. VanHook

    Science Signaling31 Jul 2012 : ec200 Full AccessRestricted Access

    The adaptor protein Sarm1 is required for Wallerian degeneration of damaged axons.

    • Abstract

  • Anchors Away

    By Nancy R. Gough

    Science Signaling31 Jul 2012 : ec201 Full AccessRestricted Access

    Monomeric Homer isoforms release receptors from multimeric Homer scaffolds to mediate synaptic modulation.

    • Abstract

  • Membrane Fusion Stimulates STING

    By John F. Foley

    Science Signaling31 Jul 2012 : ec202 Full AccessRestricted Access

    Fusion of a virus with the host cell membrane acts as a danger signal to trigger an antiviral response dependent on the adaptor STING.

    • Abstract

  • Tricky Tryps

    By Stella M. Hurtley

    Science Signaling31 Jul 2012 : ec203 Full AccessRestricted Access

    Parasites release cyclic adenosine monophosphate when swallowed up by myeloid cells, thereby turning off a host defense pathway.

    • Abstract

  • Netting the Bad Guys

    By Kristen L. Mueller

    Science Signaling31 Jul 2012 : ec204 Full AccessRestricted Access

    Rather than killing bacteria directly, a gut antimicrobial peptide forms netlike structures that ensnare invading bacteria.

    • Abstract