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Abstract
This Podcast features an interview with Susan Pierce, senior author of a Research Article published in the 31 July 2012 issue of Science Signaling. The adaptive immune system allows vertebrates to recognize specific pathogens during an infection and remember them so that a subsequent exposure to the same pathogen elicits an even stronger response. Signaling through immunoglobulin G (IgG) B cell receptors (BCRs) in memory B cells is important for the immune system’s ability to respond to reinfection with a previously encountered pathogen. Pierce discusses her group’s recent discovery of a mechanism that promotes maximal signaling through IgG BCRs to ensure that memory B cells respond rapidly and robustly.
