07 August 2012
Vol 5, Issue 236
  • Contents

    • Research Articles

    • Review

    • Podcast

      • Science Signaling Podcast: 7 August 2012

        Drugs that reduce microtubule density or prevent the production of reactive oxygen species in skeletal muscle might slow the progression of Duchenne muscular dystrophy.

    • Editors' Choice

      • SIRT-ain to Become Brown Fat

        SIRT-1–mediated deacetylation promotes the ability of PPARγ to induce the browning of white adipose tissue.

      • Hollowing Out the Center

        Lumen formation by mammary epithelial cells involves two distinct effects of cAMP signaling in the inner and outer cells.

      • Inducing Conformational Change in the Ligand

        The structure of follicle-stimulating hormone bound to the ectodomain of its receptor reveals a possible mechanism for receptor activation.

      • Initiating Mitochondrial Repair

        When stressed, the mitochondrion reduces import of a transcription factor, which enters the nucleus instead.

      • The Inner Workings of a Clock

        A circadian rhythm regulator acts by altering the elongation stage of gene expression.

      • Is Winter Past?

        Arabidopsis adjusts the onset of flowering to the length of winters via an epigenetic mechanism.

About The Cover

Cover image expansion

Online Cover This week features a Research Article that describes how contraction-induced injury to skeletal muscle in a mouse model of muscular dystrophy can be reduced by decreasing microtubule density. The image shows the microtubule network in the skeletal muscle of a normal mouse. [Image: Ramzi Khairallah and Christopher Ward/Schools of Medicine and Nursing, University of Maryland]