Contents
Vol 5, Issue 237
Contents
Research Articles
- Interference with the PTEN-MAST2 Interaction by a Viral Protein Leads to Cellular Relocalization of PTEN
The G protein of rabies virus manipulates the cellular localization of PTEN, which may promote cell survival.
- Sequential Inter- and Intrasubunit Rearrangements During Activation of Dimeric Metabotropic Glutamate Receptor 1
Both subunits in the metabotropic glutamate receptor 1 dimer move relative to each other before one adopts an active conformation.
Perspective
- L-Type Calcium Channels: On the Fast Track to Nuclear Signaling
In excitation-transcription coupling, some calcium signals are more efficient than others.
Podcast
- Science Signaling Podcast: 14 August 2012
Growth of the male rhinoceros beetle’s horn is more sensitive to insulin signaling than are other body parts.
Editors' Choice
- Cancer-Fighting Vanilloids
Endogenous vanilloids produced by neural precursor cells inhibit the growth of malignant gliomas.
- Cancer Stem Cells in Color
Multicolor reporter genes signal the fate of stem cells that fuel the growth of intestinal tumors in mice.
- How Diet and Sun Promote Inflammation
Endogenously produced danger-associated molecular patterns induced by free fatty acids and sun-damaged RNAs activate TLR4 and TLR3.
- A Caspase for Phagosomal-Lysosomal Fusion
Clearance of phagosomes containing pathogenic bacteria depends on caspase-11.
- Elimination by Extrusion
An AMPK homolog and its upstream activators are necessary for cell death by cell shedding in Caenorhabditis elegans.
- Phosphoinositide Contributions
The phospholipid phosphatidylinositol 4-phosphate defines important physical properties of the cell membrane.
- Crucial Cerebellar Glial Cells
Signaling by glial cells helps to preserve cerebellar neurons that control movements.
