Research ArticleNeuroscience The Complex of G Protein Regulator RGS9-2 and Gβ5 Controls Sensitization and Signaling Kinetics of Type 5 Adenylyl Cyclase in the Striatum Keqiang Xie1, Ikuo Masuho1, Cameron Brand2, Carmen W. Dessauer2, and Kirill A. Martemyanov1,*1Department of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.2Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center, Houston, TX 77225, USA.↵*To whom correspondence should be addressed. E-mail: kirill{at}scripps.edu See allHide authors and affiliations Science Signaling 28 Aug 2012:Vol. 5, Issue 239, pp. ra63DOI: 10.1126/scisignal.2002922 Keqiang Xie 1Department of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Ikuo Masuho 1Department of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Cameron Brand 2Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center, Houston, TX 77225, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Carmen W. Dessauer 2Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center, Houston, TX 77225, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Kirill A. Martemyanov 1Department of Neuroscience, The Scripps Research Institute, Jupiter, FL 33458, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site For correspondence: kirill@scripps.edu Article Figures & Data Info & Metrics eLetters PDF Article Information vol. 5 no. 239 ra63 DOI: https://doi.org/10.1126/scisignal.2002922 PubMed: 22932702 Published By: Science Signaling Print ISSN: 1945-0877 Online ISSN: 1937-9145 History: Received February 2, 2012Accepted August 7, 2012 . Copyright & Usage: Copyright © 2012, American Association for the Advancement of Science Author Information Altmetric Article usage Article lifetimeLast 6 monthsThis monthArticle usage: August 2012 to March 2021 AbstractFullPdf Aug 2012104653105 Sep 201277345104 Oct 20122175147 Nov 20121101524 Dec 2012117914 Jan 20131111937 Feb 2013841715 Mar 20139087 Apr 201369516 May 201367115 Jun 201358215 Jul 201377615 Aug 20133713 Sep 20133396 Oct 20132779 Nov 201339108 Dec 20133413 Jan 20143044 Feb 20142165 Mar 20143679 Apr 20142668 May 20143468 Jun 201437134 Jul 20144691 Aug 20141677 Sep 201413117 Oct 20141355 Nov 20141292 Dec 20141733 Jan 2015976 Feb 20159106 Mar 201521105 Apr 20151067 May 20151144 Jun 20151926 Jul 2015325 Aug 20151510 Sep 2015322 Oct 2015103 Nov 2015074 Dec 2015633 Jan 20163621 Feb 20161555 Mar 20162412 Apr 20163300 May 20162446 Jun 20165121 Jul 20164141 Aug 20163331 Sep 20163203 Oct 20163113 Nov 20164811 Dec 20163235 Jan 20172653 Feb 20174656 Mar 20172615 Apr 20172913 May 20172358 Jun 20171613 Jul 20172111 Aug 20174724 Sep 20173532 Oct 20171920 Nov 20172520 Dec 20171522 Jan 20184042 Feb 20184531 Mar 20182252 Apr 20183851 May 201832310 Jun 20182120 Jul 20181714 Aug 20182052 Sep 20182265 Oct 20182741 Nov 20181864 Dec 20182631 Jan 20193163 Feb 20193672 Mar 20193043 Apr 20191261 May 20191722 Jun 20191852 Jul 20191420 Aug 2019373 Sep 2019650 Oct 20191850 Nov 20192141 Dec 20192431 Jan 202022106 Feb 20201744 Mar 2020852 Apr 2020971 May 20202569 Jun 2020754 Jul 202022811 Aug 20204275 Sep 20201536 Oct 20202296 Nov 20202064 Dec 202023116 Jan 20212073 Feb 20211382 Mar 2021100 View Full Text
The Complex of G Protein Regulator RGS9-2 and Gβ5 Controls Sensitization and Signaling Kinetics of Type 5 Adenylyl Cyclase in the Striatum By Keqiang Xie, Ikuo Masuho, Cameron Brand, Carmen W. Dessauer, Kirill A. Martemyanov Science Signaling28 Aug 2012 : ra63 By suppressing cAMP production in the striatum, the RGS9-2/Gβ5 complex could affect the development of opioid addiction. Supplementary Materials
The Complex of G Protein Regulator RGS9-2 and Gβ5 Controls Sensitization and Signaling Kinetics of Type 5 Adenylyl Cyclase in the Striatum By Keqiang Xie, Ikuo Masuho, Cameron Brand, Carmen W. Dessauer, Kirill A. Martemyanov Science Signaling28 Aug 2012 : ra63 By suppressing cAMP production in the striatum, the RGS9-2/Gβ5 complex could affect the development of opioid addiction. Supplementary Materials