Contents
Vol 5, Issue 240
Contents
Research Articles
- FAM123A Binds to Microtubules and Inhibits the Guanine Nucleotide Exchange Factor ARHGEF2 to Decrease Actomyosin Contractility
Unlike related proteins, FAM123A interacts with microtubule-associated proteins and alters microtubule dynamics.
- Guanylyl Cyclases A and B Are Asymmetric Dimers That Are Allosterically Activated by ATP Binding to the Catalytic Domain
An ATP-binding allosteric site could be pharmacologically targeted to alter the activity of membrane guanylyl cyclases.
Perspective
- Allosteric Regulation of Nucleotidyl Cyclases: An Emerging Pharmacological Target
Targeting allosteric rather than catalytic sites of nucleotidyl cyclases could result in isoform specificity.
Editors' Choice
- Delivering a Proangiogenic Message in a MicroRNA-Containing Vesicle
MicroRNAs released by tumor cells activate the JAK-STAT pathway in endothelial cells, leading to migration and angiogenesis.
- Is NO a Cause for Depression?
In mice, a difference in nitric oxide concentration in the hippocampus between males and females appears to influence affective behavior.
- A G Protein Blocks the Chilling Effect
Activation of an ion channel that responds to cold temperature is inhibited by the direct association of a G protein α subunit.
- Skin Specifics
The skin microbiota play a selective role in modulating immunity in the skin of mice.
- Positive Selection
Voltage-gated sodium channels enhance Ca2+ influx in response to nonself ligands and promote the development of CD4+ T cells.
- A Double Escapee
A region of ribosomal RNA that confers antibiotic resistance is also recognized by mouse innate immune receptors.
- Stalking a Second Messenger in Eukaryotes
A signaling molecule thought to be confined to prokaryotes promotes stalk formation in food-deprived Dictyostelium.
- Linking Stress and Apoptosis to Impaired Mitochondrial Fusion
Stress induces JNK phosphorylation of a mitochondrial fusion protein, leading to its degradation, mitochondrial fragmentation, and apoptosis.
- Modulating the Clock
A small molecule binds to a core protein in the circadian clock and slows down time.
