11 September 2012
Vol 5, Issue 241

About The Cover

Cover image expansion

Online Cover This week features a Research Article that describes how the activity of the lipid kinase PI3K governs whether the protein kinase PKCα promotes the formation of invadopodia in cancer cells (also listen to the accompanying Podcast). Invadopodia are cellular protrusions that can degrade the extracellular matrix and enhance the invasiveness of cancer cells. The image shows cells with invadopodia (red) and focal adhesions (green), cellular structures that contain many of the same components as invadopodia but have decreased ability to degrade the extracellular matrix. [Image: Daisuke Hoshino/Division of Cancer Cell Research, Institute of Medical Science, University of Tokyo, Tokyo, Japan]