Contents
Vol 5, Issue 241
Contents
Research Articles
- Network Analysis of the Focal Adhesion to Invadopodia Transition Identifies a PI3K-PKCα Invasive Signaling Axis
The activity of the lipid kinase PI3K governs whether the protein kinase PKCα promotes invasive behavior of cancer cells.
- The Membrane-Bound Enzyme CD38 Exists in Two Opposing Orientations
The identification of two forms of a transmembrane enzyme suggests that flipping the catalytic domain from the outside to the inside of the cell may regulate its activity.
Perspective
- Revisiting the Nucleolus: From Marker to Dynamic Integrator of Cancer Signaling
Deregulations in ribosome biogenesis contribute to tumorigenesis and could be targeted to treat cancer.
Podcast
- Science Signaling Podcast: 11 September 2012
The activity of a lipid kinase influences the production of invadopodia by cancer cells.
Editors' Choice
- TORC4 in a Parasite’s Life Cycle
Trypanosoma brucei relies on a third TOR complex to limit differentiation from the proliferative to the quiescent form.
- JNKing Neurons
JNK3 promotes the generation of β-amyloid and ER stress in Alzheimer’s disease.
- Oncogenic TACC-tics
A fusion gene detected in a small subset of human brain tumors encodes a potentially druggable target.
- Recycle MAP, Rewind Ste5
A scaffold protein controls signal transmission by using an autoinhibitory domain as a gate.
- Bacterial Traffic Jammers
Effector proteins from bacteria inhibit Rab1 to disrupt vesicular functions and block immune responses.
- Understanding a Broken Heart
A myosin thick filament–associated sarcomeric protein modulates cardiac contractility in a phosphorylation-dependent manner.
- Responding to Light and Heat
In rhodopsin, the transition state for thermal activation has the same electronic structure as that for photoexcitation.
