18 September 2012
Vol 5, Issue 242
  • Contents

    • Research Resource

    • Perspective

    • Review

    • Editors' Choice

      • β Cells Lose Their Identity

        The dedifferentiation of pancreatic β cells into progenitor cells may underlie the development of type 2 diabetes.

      • Timing the Immune Response

        The circadian regulator CLOCK enhances the transcriptional activity of the immune regulator NF-κB.

      • Hipk Antagonizes Hippo

        A kinase opposes Hippo signaling by promoting activity of the transcriptional coactivator Yorkie.

      • Dynamic Assembly

        Spatial restraints revealed by chemical cross-linking and mass spectrometry elucidate the topology of a dynamic signaling network.

      • It’s the Pits

        A Rho guanosine triphosphatase–based regulatory mechanism reveals how plants remodel membranes and cell walls to produce various cell shapes.

      • Dissecting SNARE Zippering

        Zippering of a single SNARE complex generates high force and energy that can potentially drive synaptic membrane fusion.

About The Cover

Cover image expansion

Online Cover This week features a Research Resource that applied bioinformatics analysis to a BRCT protein-protein interaction network to identify biological processes and protein complexes that integrate the DNA damage response with regulation of the cell cycle. The image shows a network based on the tandem BRCT-mediated protein interactions. The BRCT domain–containing proteins are indicated in yellow. [Image: Chris Bickel/AAAS, adapted from Nicholas Woods and Alvaro Monteiro, Moffitt Cancer Center, Tampa, FL]