Contents
Vol 5, Issue 242
Contents
Research Resource
- Charting the Landscape of Tandem BRCT Domain–Mediated Protein Interactions
Building a protein-protein interaction network mediated by the BRCT domain reveals players in the DNA damage response.
Perspective
- Modulating Mitochondrial Intracellular Location as a Redox Signal
Hypoxia induces the redistribution of mitochondria to promote transcriptional responses to low oxygen.
Review
- Pseudogenes: Newly Discovered Players in Human Cancer
Pseudogenes can have multiple, diverse functions, affecting not only their parental genes but also unrelated genes.
Editors' Choice
- β Cells Lose Their Identity
The dedifferentiation of pancreatic β cells into progenitor cells may underlie the development of type 2 diabetes.
- Timing the Immune Response
The circadian regulator CLOCK enhances the transcriptional activity of the immune regulator NF-κB.
- Hipk Antagonizes Hippo
A kinase opposes Hippo signaling by promoting activity of the transcriptional coactivator Yorkie.
- Dynamic Assembly
Spatial restraints revealed by chemical cross-linking and mass spectrometry elucidate the topology of a dynamic signaling network.
- It’s the Pits
A Rho guanosine triphosphatase–based regulatory mechanism reveals how plants remodel membranes and cell walls to produce various cell shapes.
- Dissecting SNARE Zippering
Zippering of a single SNARE complex generates high force and energy that can potentially drive synaptic membrane fusion.
