Research ResourceProtein Domains

Charting the Landscape of Tandem BRCT Domain–Mediated Protein Interactions

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Science Signaling  18 Sep 2012:
Vol. 5, Issue 242, pp. rs6
DOI: 10.1126/scisignal.2002255

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Networking the DNA Damage Response

The protein-protein interaction domain BRCT is found in proteins that participate in the DNA damage response (DDR) and has been linked to cancer. A well-known BRCT domain–containing protein is the DDR protein BRCA1, encoded by a gene that is associated with breast cancer. Woods et al. performed systems analysis to identify proteins that interacted with BRCT domains in cells exposed to DNA damage. Bioinformatics analysis of the BRCT protein-protein interaction network revealed biological processes and protein complexes that integrate the DDR with cell cycle regulation and transcription. Because of the importance of BRCT domain–containing proteins in cancer, understanding the cellular response to DDR-inducing chemotherapy and radiation therapy can aid in the development of effective treatments.

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