Contents
Vol 5, Issue 244
Contents
Research Articles
- The Rho Exchange Factors Vav2 and Vav3 Control a Lung Metastasis–Specific Transcriptional Program in Breast Cancer Cells
Two Vav isoforms could be targeted to prevent breast tumors from metastasizing to the lung.
- An Interaction Between BZR1 and DELLAs Mediates Direct Signaling Crosstalk Between Brassinosteroids and Gibberellins in Arabidopsis
Crosstalk between two signaling pathways that control plant growth occurs through the DELLA family of transcription factors.
Perspectives
- Rho GEFs and Cancer: Linking Gene Expression and Metastatic Dissemination
The guanine exchange factors Vav2 and Vav3 regulate gene expression to promote the metastasis of breast tumors to the lung.
- HCN1 Channels: A New Therapeutic Target for Depressive Disorders?
Reduced function of hyperpolarization-activated cyclic nucleotide-gated channels alleviates depressive-like behavior in rodents.
- Inflammatory Factors Contribute to Depression and Its Comorbid Conditions
Manipulation of pro- and anti-inflammatory mediators may improve treatments for depression.
Presentations
- Circadian Rhythms of Glucocorticoid Hormone Actions in Target Tissues: Potential Clinical Implications
The circadian clock cooperates with the hypothalamic-pituitary-adrenal axis to control tissue sensitivity to diurnally fluctuating circulating glucocorticoids.
- Primary Generalized Glucocorticoid Resistance and Hypersensitivity: The End-Organ Involvement in the Stress Response
Distinct activities of glucocorticoid receptor variants and isoforms should be considered in the management of pathologic conditions treated with glucocorticoids.
Editors' Choice
- Targeting TRPV4 to Treat Metabolic Disease
Antagonism of TRPV4 channels contributes to the browning of white adipose tissue.
- ROCK Mediates Leptin Signaling
Mice lacking Rho-associated kinase have impaired sensitivity to the appetite-suppressing hormone leptin.
- Macrophages Resist the Effects of Cholesterol Buildup
Accumulation of a cholesterol precursor promotes lipid homeostasis and prevents inflammatory responses in macrophages.
- Patterning Villi
Hedgehog signaling in mesenchymal cell clusters dictates formation of villi from the intestinal epithelium.
- Keeping Cancer Cells at Bay
Polyploid cancer cells trigger an immune response owing to proteins aberrantly exposed on their outer surfaces.
- Tuberculosis Vaccine Conundrum
A mutation that accounts for adverse reactions to the Bacille Calmette-Guérin vaccine against tuberculosis is identified.
