09 October 2012
Vol 5, Issue 245

About The Cover

Cover image expansion

Online Cover This week features a Research Article describing the distinct structural features that enable three related mitogen-activated protein kinases—c-Jun N-terminal kinase (JNK), p38, and extracellular signal–regulated kinase (ERK)—to discriminate between linear docking motifs in potential binding partners. The image shows the crystal structures of a peptide derived from MNK1 (yellow) bound to ERK2 (teal), a peptide derived from NFAT (orange) bound to JNK1 (blue), and a peptide derived from MKK6 (red) bound to p38α (purple). [Image: Chris Bickel/AAAS]