Research ArticleVirology Interferon-Induced SCYL2 Limits Release of HIV-1 by Triggering PP2A-Mediated Dephosphorylation of the Viral Protein Vpu Kei Miyakawa1,2, Tatsuya Sawasaki3, Satoko Matsunaga1, Andrey Tokarev4, Gary Quinn1, Hirokazu Kimura5, Masako Nomaguchi6, Akio Adachi6, Naoki Yamamoto7, John Guatelli4,8, and Akihide Ryo1,*1Department of Microbiology, Yokohama City University School of Medicine, Kanagawa 236-0004, Japan.2Japanese Foundation for AIDS Prevention, Tokyo 101-0061, Japan.3Cell-Free Science and Technology Research Center, Ehime University, Ehime 790-8577, Japan.4Department of Medicine, University of California, La Jolla, CA 92093, USA.5Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo 208-0011, Japan.6Department of Microbiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan.7Department of Microbiology, National University of Singapore, Singapore 117597, Singapore.8San Diego Veterans Affairs Healthcare System, San Diego, CA 92161, USA.↵*To whom correspondence should be addressed. E-mail: aryo{at}yokohama-cu.ac.jp See allHide authors and affiliations Science Signaling 09 Oct 2012:Vol. 5, Issue 245, pp. ra73DOI: 10.1126/scisignal.2003212 Kei Miyakawa 1Department of Microbiology, Yokohama City University School of Medicine, Kanagawa 236-0004, Japan.2Japanese Foundation for AIDS Prevention, Tokyo 101-0061, Japan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Tatsuya Sawasaki 3Cell-Free Science and Technology Research Center, Ehime University, Ehime 790-8577, Japan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Satoko Matsunaga 1Department of Microbiology, Yokohama City University School of Medicine, Kanagawa 236-0004, Japan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Andrey Tokarev 4Department of Medicine, University of California, La Jolla, CA 92093, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Gary Quinn 1Department of Microbiology, Yokohama City University School of Medicine, Kanagawa 236-0004, Japan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Hirokazu Kimura 5Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo 208-0011, Japan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Masako Nomaguchi 6Department of Microbiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Akio Adachi 6Department of Microbiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Naoki Yamamoto 7Department of Microbiology, National University of Singapore, Singapore 117597, Singapore.Find this author on Google Scholar Find this author on PubMed Search for this author on this site John Guatelli 4Department of Medicine, University of California, La Jolla, CA 92093, USA.8San Diego Veterans Affairs Healthcare System, San Diego, CA 92161, USA.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Akihide Ryo 1Department of Microbiology, Yokohama City University School of Medicine, Kanagawa 236-0004, Japan.Find this author on Google Scholar Find this author on PubMed Search for this author on this site For correspondence: aryo@yokohama-cu.ac.jp Article Figures & Data Info & Metrics eLetters PDF Article Information vol. 5 no. 245 ra73 DOI: https://doi.org/10.1126/scisignal.2003212 PubMed: 23047923 Published By: Science Signaling Print ISSN: 1945-0877 Online ISSN: 1937-9145 History: Received May 11, 2012Accepted September 20, 2012 . 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Interferon-Induced SCYL2 Limits Release of HIV-1 by Triggering PP2A-Mediated Dephosphorylation of the Viral Protein Vpu By Kei Miyakawa, Tatsuya Sawasaki, Satoko Matsunaga, Andrey Tokarev, Gary Quinn, Hirokazu Kimura, Masako Nomaguchi, Akio Adachi, Naoki Yamamoto, John Guatelli, Akihide Ryo Science Signaling09 Oct 2012 : ra73 HIV-infected cells dephosphorylate and inactivate a viral factor to restrict viral spreading. Supplementary Materials
Interferon-Induced SCYL2 Limits Release of HIV-1 by Triggering PP2A-Mediated Dephosphorylation of the Viral Protein Vpu By Kei Miyakawa, Tatsuya Sawasaki, Satoko Matsunaga, Andrey Tokarev, Gary Quinn, Hirokazu Kimura, Masako Nomaguchi, Akio Adachi, Naoki Yamamoto, John Guatelli, Akihide Ryo Science Signaling09 Oct 2012 : ra73 HIV-infected cells dephosphorylate and inactivate a viral factor to restrict viral spreading. Supplementary Materials