Interferon-Induced SCYL2 Limits Release of HIV-1 by Triggering PP2A-Mediated Dephosphorylation of the Viral Protein Vpu

Kei Miyakawa; Tatsuya Sawasaki; Satoko Matsunaga; Andrey Tokarev; Gary Quinn; Hirokazu Kimura; Masako Nomaguchi; Akio Adachi; Naoki Yamamoto; John Guatelli; Akihide Ryo

doi:10.1126/scisignal.2003212

Research ArticleVirology

Interferon-Induced SCYL2 Limits Release of HIV-1 by Triggering PP2A-Mediated Dephosphorylation of the Viral Protein Vpu

Kei Miyakawa¹,²,
Tatsuya Sawasaki³,
Satoko Matsunaga¹,
Andrey Tokarev⁴,
Gary Quinn¹,
Hirokazu Kimura⁵,
Masako Nomaguchi⁶,
Akio Adachi⁶,
Naoki Yamamoto⁷,
John Guatelli⁴,⁸, and
Akihide Ryo¹,*

¹Department of Microbiology, Yokohama City University School of Medicine, Kanagawa 236-0004, Japan.
²Japanese Foundation for AIDS Prevention, Tokyo 101-0061, Japan.
³Cell-Free Science and Technology Research Center, Ehime University, Ehime 790-8577, Japan.
⁴Department of Medicine, University of California, La Jolla, CA 92093, USA.
⁵Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo 208-0011, Japan.
⁶Department of Microbiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan.
⁷Department of Microbiology, National University of Singapore, Singapore 117597, Singapore.
⁸San Diego Veterans Affairs Healthcare System, San Diego, CA 92161, USA.

↵*To whom correspondence should be addressed. E-mail: aryo{at}yokohama-cu.ac.jp

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Science Signaling 09 Oct 2012:
Vol. 5, Issue 245, pp. ra73
DOI: 10.1126/scisignal.2003212

Kei Miyakawa

1Department of Microbiology, Yokohama City University School of Medicine, Kanagawa 236-0004, Japan.

2Japanese Foundation for AIDS Prevention, Tokyo 101-0061, Japan.

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Tatsuya Sawasaki

3Cell-Free Science and Technology Research Center, Ehime University, Ehime 790-8577, Japan.

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Satoko Matsunaga

1Department of Microbiology, Yokohama City University School of Medicine, Kanagawa 236-0004, Japan.

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Andrey Tokarev

4Department of Medicine, University of California, La Jolla, CA 92093, USA.

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Gary Quinn

1Department of Microbiology, Yokohama City University School of Medicine, Kanagawa 236-0004, Japan.

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Hirokazu Kimura

5Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo 208-0011, Japan.

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Masako Nomaguchi

6Department of Microbiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan.

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Akio Adachi

6Department of Microbiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan.

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Naoki Yamamoto

7Department of Microbiology, National University of Singapore, Singapore 117597, Singapore.

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John Guatelli

4Department of Medicine, University of California, La Jolla, CA 92093, USA.

8San Diego Veterans Affairs Healthcare System, San Diego, CA 92161, USA.

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Akihide Ryo

1Department of Microbiology, Yokohama City University School of Medicine, Kanagawa 236-0004, Japan.

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For correspondence: aryo@yokohama-cu.ac.jp

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Interferon-Induced SCYL2 Limits Release of HIV-1 by Triggering PP2A-Mediated Dephosphorylation of the Viral Protein Vpu

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