Research ArticleVirology
Interferon-Induced SCYL2 Limits Release of HIV-1 by Triggering PP2A-Mediated Dephosphorylation of the Viral Protein Vpu
- Kei Miyakawa1,2,
- Tatsuya Sawasaki3,
- Satoko Matsunaga1,
- Andrey Tokarev4,
- Gary Quinn1,
- Hirokazu Kimura5,
- Masako Nomaguchi6,
- Akio Adachi6,
- Naoki Yamamoto7,
- John Guatelli4,8, and
- Akihide Ryo1,*
- 1Department of Microbiology, Yokohama City University School of Medicine, Kanagawa 236-0004, Japan.
- 2Japanese Foundation for AIDS Prevention, Tokyo 101-0061, Japan.
- 3Cell-Free Science and Technology Research Center, Ehime University, Ehime 790-8577, Japan.
- 4Department of Medicine, University of California, La Jolla, CA 92093, USA.
- 5Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo 208-0011, Japan.
- 6Department of Microbiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima 770-8503, Japan.
- 7Department of Microbiology, National University of Singapore, Singapore 117597, Singapore.
- 8San Diego Veterans Affairs Healthcare System, San Diego, CA 92161, USA.
- ↵*To whom correspondence should be addressed. E-mail: aryo{at}yokohama-cu.ac.jp
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Science Signaling 09 Oct 2012:
Vol. 5, Issue 245, pp. ra73
DOI: 10.1126/scisignal.2003212
