Specificity of Linear Motifs That Bind to a Common Mitogen-Activated Protein Kinase Docking Groove

Ágnes Garai; András Zeke; Gergő Gógl; Imre Törő; Ferenc Fördős; Hagen Blankenburg; Tünde Bárkai; János Varga; Anita Alexa; Dorothea Emig; Mario Albrecht; Attila Reményi

doi:10.1126/scisignal.2003004

Research ArticleStructural Biology

Specificity of Linear Motifs That Bind to a Common Mitogen-Activated Protein Kinase Docking Groove

Ágnes Garai¹,*,
András Zeke¹,*,
Gergő Gógl¹,*,
Imre Törő¹,
Ferenc Fördős¹,
Hagen Blankenburg²,
Tünde Bárkai¹,³,
János Varga¹,
Anita Alexa¹,
Dorothea Emig²,
Mario Albrecht²,⁴, and
Attila Reményi¹,†

¹Department of Biochemistry, Eötvös Loránd University, Pázmány Péter sétány 1/C, 1117 Budapest, Hungary.
²Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, 66123 Saarbrücken, Germany.
³Protein Lab, Chemical Research Centre, Hungarian Academy of Sciences, 1025 Budapest, Hungary.
⁴Department of Bioinformatics, Institute of Biometrics and Medical Informatics, University Medicine Greifswald, 17475 Greifswald, Germany.

↵†To whom correspondence should be addressed. E-mail: remenyi{at}elte.hu

↵* These authors contributed equally to this work.

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Science Signaling 09 Oct 2012:
Vol. 5, Issue 245, pp. ra74
DOI: 10.1126/scisignal.2003004

Ágnes Garai

1Department of Biochemistry, Eötvös Loránd University, Pázmány Péter sétány 1/C, 1117 Budapest, Hungary.

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András Zeke

1Department of Biochemistry, Eötvös Loránd University, Pázmány Péter sétány 1/C, 1117 Budapest, Hungary.

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Gergő Gógl

1Department of Biochemistry, Eötvös Loránd University, Pázmány Péter sétány 1/C, 1117 Budapest, Hungary.

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Imre Törő

1Department of Biochemistry, Eötvös Loránd University, Pázmány Péter sétány 1/C, 1117 Budapest, Hungary.

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Ferenc Fördős

1Department of Biochemistry, Eötvös Loránd University, Pázmány Péter sétány 1/C, 1117 Budapest, Hungary.

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Hagen Blankenburg

2Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, 66123 Saarbrücken, Germany.

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Tünde Bárkai

1Department of Biochemistry, Eötvös Loránd University, Pázmány Péter sétány 1/C, 1117 Budapest, Hungary.

3Protein Lab, Chemical Research Centre, Hungarian Academy of Sciences, 1025 Budapest, Hungary.

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János Varga

1Department of Biochemistry, Eötvös Loránd University, Pázmány Péter sétány 1/C, 1117 Budapest, Hungary.

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Anita Alexa

1Department of Biochemistry, Eötvös Loránd University, Pázmány Péter sétány 1/C, 1117 Budapest, Hungary.

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Dorothea Emig

2Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, 66123 Saarbrücken, Germany.

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Mario Albrecht

2Department of Computational Biology and Applied Algorithmics, Max Planck Institute for Informatics, 66123 Saarbrücken, Germany.

4Department of Bioinformatics, Institute of Biometrics and Medical Informatics, University Medicine Greifswald, 17475 Greifswald, Germany.

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Attila Reményi

1Department of Biochemistry, Eötvös Loránd University, Pázmány Péter sétány 1/C, 1117 Budapest, Hungary.

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For correspondence: remenyi@elte.hu

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Specificity of Linear Motifs That Bind to a Common Mitogen-Activated Protein Kinase Docking Groove

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