Contents
Vol 5, Issue 246
Contents
Research Articles
- TWEAK and cIAP1 Regulate Myoblast Fusion Through the Noncanonical NF-κB Signaling Pathway
Muscle fiber formation from progenitor cells is dependent on noncanonical NF-κB signaling.
- The Temporal Pattern of Stimulation Determines the Extent and Duration of MAPK Activation in a Caenorhabditis elegans Sensory Neuron
Live-cell imaging in nematodes reveals the complex responses of a mitogen-activated protein kinase to neuronal stimulation.
Perspective
- The Response of Cancers to BRAF Inhibition Underscores the Importance of Cancer Systems Biology
Targeting the receptor and a mutant component may be an effective colon cancer treatment.
Review
- The Hedgehog Signal Transduction Network
The Hedgehog network includes canonical and noncanonical signaling modules important for development, homeostasis, and disease.
Presentation
- Neurosteroids and Microneurotrophins Signal Through NGF Receptors to Induce Prosurvival Signaling in Neuronal Cells
Synthetic DHEA analogs promote neuronal survival without estrogenic or androgenic side effects.
Editors' Choice
- Internalization as Activation
In plants, receptor internalization promotes G protein signaling.
- Hippo Blocks the Way
The Hippo pathway inhibits metastasis of breast cancer cells, a role that is stimulated by the LIF receptor and inhibited by miR-9.
- Neutrophils Generate Their Own Activators
Cathepsin G secreted from neutrophils cleaves proinflammatory precursors that function as autocrine signals.
- Cheat Control
Cooperating groups of bacteria resist infiltration by noncooperating cheats by co-regulating shared and individual products.
- Pkd2 Knows the Flow
A calcium channel in the nonmotile cilia of crown cells contributes to left-right patterning.
- Feeling the Light
Light sensing involves contraction of the photoreceptor cell membrane physically gating the light-sensitive channels.
