Akt Phosphorylates the Transcriptional Repressor Bmi1 to Block Its Effects on the Tumor-Suppressing Ink4a-Arf Locus

Yan Liu; Fan Liu; Hao Yu; Xinyang Zhao; Goro Sashida; Anthony Deblasio; Michael Harr; Qing-Bai She; Zhenbang Chen; Hui-Kuan Lin; Silvana Di Giandomenico; Shannon E. Elf; Youyang Yang; Yasuhiko Miyata; Gang Huang; Silvia Menendez; Ingo K. Mellinghoff; Neal Rosen; Pier Paolo Pandolfi; Cyrus V. Hedvat; Stephen D. Nimer

doi:10.1126/scisignal.2003199

Research ArticleCancer

Akt Phosphorylates the Transcriptional Repressor Bmi1 to Block Its Effects on the Tumor-Suppressing Ink4a-Arf Locus

Yan Liu¹,²,*,
Fan Liu¹,
Hao Yu²,
Xinyang Zhao¹,
Goro Sashida¹,
Anthony Deblasio¹,
Michael Harr¹,
Qing-Bai She¹,
Zhenbang Chen³,
Hui-Kuan Lin³,
Silvana Di Giandomenico¹,
Shannon E. Elf¹,
Youyang Yang¹,
Yasuhiko Miyata¹,
Gang Huang¹,
Silvia Menendez¹,
Ingo K. Mellinghoff⁴,
Neal Rosen¹,
Pier Paolo Pandolfi³,
Cyrus V. Hedvat⁵, and
Stephen D. Nimer¹,⁶,*

¹Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
²Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
³Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
⁴Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
⁵Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
⁶Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

↵*To whom correspondence should be addressed. E-mail: liu219{at}iupui.edu (Y.L.); snimer{at}med.miami.edu (S.D.N.)

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Science Signaling 23 Oct 2012:
Vol. 5, Issue 247, pp. ra77
DOI: 10.1126/scisignal.2003199

Yan Liu

1Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

2Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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For correspondence: liu219@iupui.edu snimer@med.miami.edu

Fan Liu

1Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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Hao Yu

2Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

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Xinyang Zhao

1Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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Goro Sashida

1Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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Anthony Deblasio

1Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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Michael Harr

1Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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Qing-Bai She

1Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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Zhenbang Chen

3Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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Hui-Kuan Lin

3Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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Silvana Di Giandomenico

1Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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Shannon E. Elf

1Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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Youyang Yang

1Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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Yasuhiko Miyata

1Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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Gang Huang

1Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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Silvia Menendez

1Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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Ingo K. Mellinghoff

4Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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Neal Rosen

1Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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Pier Paolo Pandolfi

3Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

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Cyrus V. Hedvat

5Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

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Stephen D. Nimer

1Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.

6Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

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For correspondence: liu219@iupui.edu snimer@med.miami.edu

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Akt Phosphorylates the Transcriptional Repressor Bmi1 to Block Its Effects on the Tumor-Suppressing Ink4a-Arf Locus

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