Contents

Contents

• Research Article

  • Mice Lacking the ITIM-Containing Receptor G6b-B Exhibit Macrothrombocytopenia and Aberrant Platelet Function

    By Alexandra Mazharian, Ying-Jie Wang, Jun Mori, Danai Bem, Brenda Finney, Silke Heising, Paul Gissen, James G. White, Michael C. Berndt, Elizabeth E. Gardiner, Bernhard Nieswandt, Michael R. Douglas, Robert D. Campbell, Steve P. Watson, Yotis A. Senis

    Science Signaling30 Oct 2012 : ra78 Full AccessRestricted Access

    An inhibitory receptor ensures that megakaryocytes produce proper numbers of functional platelets.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF

• Meeting Report

  • Stress Response and Child Health

    By Evangelia Charmandari, John C. Achermann, Jean-Claude Carel, Olle Soder, George P. Chrousos

    Science Signaling30 Oct 2012 : mr1 Full AccessRestricted Access

    Endocrine and inflammatory responses to stress affect many aspects of development, physiology, and cognition.

    • Abstract
    • Full Text
    • PDF

• Presentations

  • Prenatal Stress, Telomere Biology, and Fetal Programming of Health and Disease Risk

    By Sonja Entringer, Claudia Buss, Pathik D. Wadhwa

    Science Signaling30 Oct 2012 : pt12 Full AccessRestricted Access

    Telomere biology may mediate the effects of intrauterine stress on subsequent newborn, child, and adult health and disease risk outcomes.

    • Abstract
    • Full Text
    • PDF

  • Protein Complexes and Target Genes Identification by in Vivo Biotinylation: The STAT5 Paradigm

    By Eleni Katsantoni

    Science Signaling30 Oct 2012 : pt13 Full AccessRestricted Access

    Identification of a transcription factor’s interacting partners and target genes can reveal context-specific signaling and transcriptional outputs.

    • Abstract
    • Full Text
    • PDF

• Podcast

  • Science Signaling Podcast: 30 October 2012

    By Yotis A. Senis, Annalisa M. VanHook

    Science Signaling30 Oct 2012 : pc24 Full AccessRestricted Access

    Mice lacking an inhibitory receptor have defects in the number, size, and function of platelets.

    • Abstract
    • Full Text

• Editors' Choice

  • Phosphatase-Dependent Inhibition of NF-κB

    By John F. Foley

    Science Signaling30 Oct 2012 : ec277 Full AccessRestricted Access

    A phosphatase-containing complex inhibits NF-κB signaling in T cells.

    • Abstract

  • ERK Activation Without Ras

    By Nancy R. Gough

    Science Signaling30 Oct 2012 : ec278 Full AccessRestricted Access

    The adaptor Bam32 mediates a pathway involving phospholipase C and the kinase Pak to activate the MAPK pathway independently of guanosine triphosphatases.

    • Abstract

  • Conserved Behavioral Controller

    By Annalisa M. VanHook

    Science Signaling30 Oct 2012 : ec279 Full AccessRestricted Access

    A neuropeptide related to oxytocin and vasopressin controls mating behavior and associative learning in nematodes.

    • Abstract

  • On the Receiving End

    By Pamela J. Hines

    Science Signaling30 Oct 2012 : ec280 Full AccessRestricted Access

    A protein in a hippocampal postsynaptic neuron templates transmitter release kinetics in its presynaptic neuron.

    • Abstract

  • A Partner for Smoothened in Cilia

    By Annalisa M. VanHook

    Science Signaling30 Oct 2012 : ec281 Full AccessRestricted Access

    A protein implicated in inherited ciliopathies recruits Smoothened to a ciliary microdomain and is required for Hedgehog signaling.

    • Abstract

  • Inducing Pluripotency Innately

    By Ernesto Andrianantoandro

    Science Signaling30 Oct 2012 : ec282 Full AccessRestricted Access

    Innate immunity signals enable exogenously delivered transcription factors to induce pluripotency.

    • Abstract

  • Mastering Early Divisions

    By Stella M. Hurtley

    Science Signaling30 Oct 2012 : ec283 Full AccessRestricted Access

    The protein XErp1 regulates cell cycle progression in frog embryos by inhibiting the anaphase-promoting complex/cyclosome.

    • Abstract