Contents
Vol 5, Issue 248
Contents
Research Article
- Mice Lacking the ITIM-Containing Receptor G6b-B Exhibit Macrothrombocytopenia and Aberrant Platelet Function
An inhibitory receptor ensures that megakaryocytes produce proper numbers of functional platelets.
Meeting Report
- Stress Response and Child Health
Endocrine and inflammatory responses to stress affect many aspects of development, physiology, and cognition.
Presentations
- Prenatal Stress, Telomere Biology, and Fetal Programming of Health and Disease Risk
Telomere biology may mediate the effects of intrauterine stress on subsequent newborn, child, and adult health and disease risk outcomes.
- Protein Complexes and Target Genes Identification by in Vivo Biotinylation: The STAT5 Paradigm
Identification of a transcription factor’s interacting partners and target genes can reveal context-specific signaling and transcriptional outputs.
Podcast
- Science Signaling Podcast: 30 October 2012
Mice lacking an inhibitory receptor have defects in the number, size, and function of platelets.
Editors' Choice
- Phosphatase-Dependent Inhibition of NF-κB
A phosphatase-containing complex inhibits NF-κB signaling in T cells.
- ERK Activation Without Ras
The adaptor Bam32 mediates a pathway involving phospholipase C and the kinase Pak to activate the MAPK pathway independently of guanosine triphosphatases.
- Conserved Behavioral Controller
A neuropeptide related to oxytocin and vasopressin controls mating behavior and associative learning in nematodes.
- On the Receiving End
A protein in a hippocampal postsynaptic neuron templates transmitter release kinetics in its presynaptic neuron.
- A Partner for Smoothened in Cilia
A protein implicated in inherited ciliopathies recruits Smoothened to a ciliary microdomain and is required for Hedgehog signaling.
- Inducing Pluripotency Innately
Innate immunity signals enable exogenously delivered transcription factors to induce pluripotency.
- Mastering Early Divisions
The protein XErp1 regulates cell cycle progression in frog embryos by inhibiting the anaphase-promoting complex/cyclosome.
