Contents

Contents

• Research Articles

  • Key Roles for the Lipid Signaling Enzyme Phospholipase D1 in the Tumor Microenvironment During Tumor Angiogenesis and Metastasis

    By Qin Chen, Tsunaki Hongu, Takanobu Sato, Yi Zhang, Wahida Ali, Julie-Ann Cavallo, Adrianus van der Velden, Huasong Tian, Gilbert Di Paolo, Bernhard Nieswandt, Yasunori Kanaho, Michael A. Frohman

    Science Signaling06 Nov 2012 : ra79 Full AccessRestricted Access

    Genetic ablation or pharmacological inhibition of a lipid signaling enzyme attenuates tumor growth and metastasis.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

  • Proliferative and Antiapoptotic Signaling Stimulated by Nuclear-Localized PDK1 Results in Oncogenesis

    By Chintan K. Kikani, Erik V. Verona, Jiyoon Ryu, Yanying Shen, Qingqing Ye, Li Zheng, Ziliang Qian, Hiroshi Sakaue, Kyoko Nakamura, Jie Du, Qunsheng Ji, Wataru Ogawa, Lu-Zhe Sun, Lily Q. Dong, Feng Liu

    Science Signaling06 Nov 2012 : ra80 Full AccessRestricted Access

    PDK1 in the nucleus drives oncogenesis in mice and correlates with human prostate tumor grade.

    • Editor's Summary
    • Abstract
    • Full Text
    • PDF
    • Supplementary Materials

• Perspectives

  • Sexy DEG/ENaC Channels Involved in Gustatory Detection of Fruit Fly Pheromones

    By Claudio W. Pikielny

    Science Signaling06 Nov 2012 : pe48 Full AccessRestricted Access

    DEG/ENaC channels allow male fruit flies to “taste” their mates.

    • Abstract
    • Full Text
    • PDF

  • Grb2, a Double-Edged Sword of Receptor Tyrosine Kinase Signaling

    By Artur A. Belov, Moosa Mohammadi

    Science Signaling06 Nov 2012 : pe49 Full AccessRestricted Access

    The adaptor Grb2 plays both positive and negative roles in FGF receptor signaling.

    • Abstract
    • Full Text
    • PDF

• Podcast

  • Science Signaling Podcast: 6 November 2012

    By Michael A. Frohman, Annalisa M. VanHook

    Science Signaling06 Nov 2012 : pc25 Full AccessRestricted Access

    A lipid signaling enzyme promotes the growth, vascularization, and metastasis of tumors in mice.

    • Abstract
    • Full Text

• Editors' Choice

  • Estrogens Block p53 in Breast Cancer

    By John F. Foley

    Science Signaling06 Nov 2012 : ec284 Full AccessRestricted Access

    In estrogen receptor–dependent breast cancer cells, estrogen signaling antagonizes the proapoptotic function of the tumor suppressor p53.

    • Abstract

  • Chloroplast Rescued by Ubiquitin

    By Stella M. Hurtley

    Science Signaling06 Nov 2012 : ec285 Full AccessRestricted Access

    Protein degradation helps to coordinate the growth of chloroplasts with that of the whole plant.

    • Abstract

  • Necrophilic Bandit Fungi

    By Pamela J. Hines

    Science Signaling06 Nov 2012 : ec286 Full AccessRestricted Access

    Cochliobolus victoriae, a necrotrophic fungal pathogen with devastating effects on oat crops, reveals its strategies.

    • Abstract

  • Connecting TrkB to Dendritic Remodeling

    By Nancy R. Gough

    Science Signaling06 Nov 2012 : ec287 Full AccessRestricted Access

    Serine phosphorylation of the neurotrophin receptor TrkB by Cdk5 contributes to synaptic plasticity and memory in mice.

    • Abstract

  • Promoting the Apoptotic Activity of c-Jun

    By Ernesto Andrianantoandro

    Science Signaling06 Nov 2012 : ec288 Full AccessRestricted Access

    AATF (apoptosis-antagonizing transcription factor) promotes activation of c-Jun to drive apoptosis.

    • Abstract