Contents
Vol 5, Issue 249
Contents
Research Articles
- Key Roles for the Lipid Signaling Enzyme Phospholipase D1 in the Tumor Microenvironment During Tumor Angiogenesis and Metastasis
Genetic ablation or pharmacological inhibition of a lipid signaling enzyme attenuates tumor growth and metastasis.
- Proliferative and Antiapoptotic Signaling Stimulated by Nuclear-Localized PDK1 Results in Oncogenesis
PDK1 in the nucleus drives oncogenesis in mice and correlates with human prostate tumor grade.
Perspectives
- Sexy DEG/ENaC Channels Involved in Gustatory Detection of Fruit Fly Pheromones
DEG/ENaC channels allow male fruit flies to “taste” their mates.
- Grb2, a Double-Edged Sword of Receptor Tyrosine Kinase Signaling
The adaptor Grb2 plays both positive and negative roles in FGF receptor signaling.
Podcast
- Science Signaling Podcast: 6 November 2012
A lipid signaling enzyme promotes the growth, vascularization, and metastasis of tumors in mice.
Editors' Choice
- Estrogens Block p53 in Breast Cancer
In estrogen receptor–dependent breast cancer cells, estrogen signaling antagonizes the proapoptotic function of the tumor suppressor p53.
- Chloroplast Rescued by Ubiquitin
Protein degradation helps to coordinate the growth of chloroplasts with that of the whole plant.
- Necrophilic Bandit Fungi
Cochliobolus victoriae, a necrotrophic fungal pathogen with devastating effects on oat crops, reveals its strategies.
- Connecting TrkB to Dendritic Remodeling
Serine phosphorylation of the neurotrophin receptor TrkB by Cdk5 contributes to synaptic plasticity and memory in mice.
- Promoting the Apoptotic Activity of c-Jun
AATF (apoptosis-antagonizing transcription factor) promotes activation of c-Jun to drive apoptosis.