Science Signaling Podcast: 6 November 2012

See allHide authors and affiliations

Science Signaling  06 Nov 2012:
Vol. 5, Issue 249, pp. pc25
DOI: 10.1126/scisignal.2003723

You are currently viewing the abstract.

View Full Text

Log in to view the full text

Log in through your institution

Log in through your institution


This is an interview with Michael Frohman, senior author of a Research Article that appears in this issue of Science Signaling. Frohman’s group has investigated the role of the enzyme phospholipase D1 (PLD1) in the tumor microenvironment. PLD1 produces the lipid phosphatidic acid, which acts as a second messenger in many signaling pathways and promotes proliferation, survival, and metastasis of cancer cells. When tumor cells were implanted into mice lacking PLD1, the resulting tumors were smaller and less vascularized than those that developed in wild-type mice and produced fewer lung metastases. Treating wild-type mice with a PLD1 inhibitor also inhibited tumor growth and metastasis, suggesting that inhibiting the activity of PLD1 might be a useful approach for treating human cancers.

View Full Text

Stay Connected to Science Signaling

Editor's Blog