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vol. 5 no. 249 ra80
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History:
- Received March 22, 2012
- Accepted October 19, 2012
- .
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Copyright © 2012, American Association for the Advancement of Science
Research ArticleCell Biology
Proliferative and Antiapoptotic Signaling Stimulated by Nuclear-Localized PDK1 Results in Oncogenesis
- Chintan K. Kikani1,*,
- Erik V. Verona2,
- Jiyoon Ryu2,
- Yanying Shen3,
- Qingqing Ye4,
- Li Zheng4,
- Ziliang Qian4,
- Hiroshi Sakaue5,
- Kyoko Nakamura5,
- Jie Du6,
- Qunsheng Ji4,
- Wataru Ogawa5,
- Lu-Zhe Sun2,
- Lily Q. Dong2,7,8, and
- Feng Liu1,7,8,†
- 1Department of Biochemistry, University of Texas Health Science Center, San Antonio, TX 78229, USA.
- 2Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229, USA.
- 3Department of Pathology, Shanghai Renji Hospital, Shanghai Jiaotong University, 1630 Dongfang Road, Shanghai 200127, China.
- 4AstraZeneca Innovation Center of China, 898 Halei Road, Shanghai 201203, China.
- 5Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
- 6Beijing Anzhen Hospital Affiliated to the Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing 100029, China.
- 7Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229, USA.
- 8The Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX 78229, USA.
- ↵†To whom correspondence should be addressed. E-mail: liuf{at}uthscsa.edu
-
↵* Present address: Department of Biochemistry, University of Utah School of Medicine, University of Utah, 15 N Medical Drive East, Salt Lake City, UT 84112, USA.
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Science Signaling 06 Nov 2012:
Vol. 5, Issue 249, pp. ra80
DOI: 10.1126/scisignal.2003065
Vol. 5, Issue 249, pp. ra80
DOI: 10.1126/scisignal.2003065
Chintan K. Kikani
1Department of Biochemistry, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Erik V. Verona
2Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Jiyoon Ryu
2Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Yanying Shen
3Department of Pathology, Shanghai Renji Hospital, Shanghai Jiaotong University, 1630 Dongfang Road, Shanghai 200127, China.
Qingqing Ye
4AstraZeneca Innovation Center of China, 898 Halei Road, Shanghai 201203, China.
Li Zheng
4AstraZeneca Innovation Center of China, 898 Halei Road, Shanghai 201203, China.
Ziliang Qian
4AstraZeneca Innovation Center of China, 898 Halei Road, Shanghai 201203, China.
Hiroshi Sakaue
5Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Kyoko Nakamura
5Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Jie Du
6Beijing Anzhen Hospital Affiliated to the Capital Medical University and Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing 100029, China.
Qunsheng Ji
4AstraZeneca Innovation Center of China, 898 Halei Road, Shanghai 201203, China.
Wataru Ogawa
5Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.
Lu-Zhe Sun
2Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Lily Q. Dong
2Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX 78229, USA.
7Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229, USA.
8The Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Feng Liu
1Department of Biochemistry, University of Texas Health Science Center, San Antonio, TX 78229, USA.
7Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229, USA.
8The Barshop Center for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX 78229, USA.
