Contents
Vol 5, Issue 250
Contents
Research Articles
- Single Amino Acid Substitutions Confer the Antiviral Activity of the TRAF3 Adaptor Protein onto TRAF5
Two single amino acid changes enable the adaptor protein TRAF5 to promote antiviral responses.
- The Tetraspanin CD37 Orchestrates the α4β1 Integrin–Akt Signaling Axis and Supports Long-Lived Plasma Cell Survival
Antibody-producing B cells require CD37-dependent integrin signaling for long-term survival.
Perspective
- PTEN: An Intercellular Peacekeeper?
Transfer of PTEN between cells has potential as an intercellular form of tumor suppression.
Editors' Choice
- The Noninflammatory Side of TLR2
Toll-like receptor 2 promotes tumorigenesis in a mouse model of gastric cancer, but not by enhancing inflammation.
- Preventing Tumorigenesis, Promoting Tissue Repair
Regulation of a soluble inhibitor of the cytokine IL-22 is key to enabling tissue repair but preventing tumorigenesis.
- Triple Therapy Targets Tumors
Combined targeting of the receptors HER2 and VEGFR delays the growth of HER2-positive breast cancer metastases in mouse brain.
- Wound Healing and Immunity
Tagging adenovirus with a serum protein prompts an immune response when the virus enters cells.
- ADP Ribosylation in the ER Stress Response
The poly(ADP-ribose) polymerase PARP16 modifies two kinases involved in the unfolded protein response pathway to enhance their activity.
- To Die For
Protein misfolding stimulates the destruction of microRNAs and the synthesis of an enzyme that promotes cell death.
- Shuttling Plasticity
Nucleocytoplasmic shuttling of the catalytically inactive histone deacetylase HDAC4 is important for memory.
