Research ArticleCOMPUTATIONAL BIOLOGY Attractor Landscape Analysis Reveals Feedback Loops in the p53 Network That Control the Cellular Response to DNA Damage Minsoo Choi1,*, Jue Shi2,*, Sung Hoon Jung1,3, Xi Chen2, and Kwang-Hyun Cho1,†1Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea.2Center for Quantitative Systems Biology and Department of Physics, Hong Kong Baptist University, Hong Kong, China.3Department of Information and Communication Engineering, Hansung University, Seoul 136-792, Republic of Korea.↵†To whom correspondence should be addressed. E-mail: ckh{at}kaist.ac.kr ↵* These authors contributed equally to this work. See allHide authors and affiliations Science Signaling 20 Nov 2012:Vol. 5, Issue 251, pp. ra83DOI: 10.1126/scisignal.2003363 Minsoo Choi 1Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Jue Shi 2Center for Quantitative Systems Biology and Department of Physics, Hong Kong Baptist University, Hong Kong, China.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Sung Hoon Jung 1Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea.3Department of Information and Communication Engineering, Hansung University, Seoul 136-792, Republic of Korea.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Xi Chen 2Center for Quantitative Systems Biology and Department of Physics, Hong Kong Baptist University, Hong Kong, China.Find this author on Google Scholar Find this author on PubMed Search for this author on this site Kwang-Hyun Cho 1Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea.Find this author on Google Scholar Find this author on PubMed Search for this author on this site For correspondence: ckh@kaist.ac.kr Article Figures & Data Info & Metrics eLetters PDF Article Information vol. 5 no. 251 ra83 DOI: https://doi.org/10.1126/scisignal.2003363 PubMed: 23169817 Published By: Science Signaling Print ISSN: 1945-0877 Online ISSN: 1937-9145 History: Received July 2, 2012Accepted October 31, 2012 . Copyright & Usage: Copyright © 2012, American Association for the Advancement of Science Author Information Altmetric Article usage Article lifetimeLast 6 monthsThis monthArticle usage: November 2012 to January 2021 AbstractFullPdf Nov 20122439350637 Dec 201242273158 Jan 201335789108 Feb 201325786140 Mar 20131804367 Apr 20131704449 May 20131694579 Jun 20131484656 Jul 2013951635 Aug 20131051424 Sep 20131281438 Oct 20131572249 Nov 20131022744 Dec 20131322837 Jan 20141123231 Feb 20141052127 Mar 2014896831 Apr 20141033935 May 20141201333 Jun 20141002342 Jul 2014784532 Aug 201430258 Sep 2014583327 Oct 2014352124 Nov 2014523325 Dec 2014453215 Jan 2015673524 Feb 20153083232 Mar 2015262823 Apr 2015341914 May 2015342624 Jun 2015531016 Jul 201545912 Aug 201511921 Sep 2015271519 Oct 2015776 Nov 201523515 Dec 2015421118 Jan 2016991519 Feb 2016751117 Mar 201699760 Apr 2016781311 May 201666810 Jun 201686124 Jul 201691147 Aug 201668713 Sep 201610078 Oct 20161001015 Nov 2016871514 Dec 20167059 Jan 20176713 Feb 20178488 Mar 20177858 Apr 20171591817 May 201772811 Jun 2017611110 Jul 201767119 Aug 201782135 Sep 201775158 Oct 2017571112 Nov 2017731213 Dec 2017771523 Jan 20181341832 Feb 201867182 Mar 201882308 Apr 2018993118 May 20181132628 Jun 2018761536 Jul 2018731318 Aug 2018412110 Sep 2018432211 Oct 2018412310 Nov 201861141 Dec 201862287 Jan 201971259 Feb 2019742816 Mar 2019412520 Apr 201945154 May 201934162 Jun 201942134 Jul 2019701811 Aug 201999206 Sep 2019511111 Oct 201950168 Nov 20193796 Dec 20193975 Jan 202050304 Feb 202034423 Mar 202027228 Apr 202025159 May 202054127 Jun 202024246 Jul 20204182 Aug 2020222110 Sep 202039216 Oct 2020573411 Nov 202047187 Dec 2020552811 Jan 202131268 View Full Text
Attractor Landscape Analysis Reveals Feedback Loops in the p53 Network That Control the Cellular Response to DNA Damage By Minsoo Choi, Jue Shi, Sung Hoon Jung, Xi Chen, Kwang-Hyun Cho Science Signaling20 Nov 2012 : ra83 State-space analysis of the p53 network identifies a therapeutic strategy for treating cancer. Supplementary Materials
Attractor Landscape Analysis Reveals Feedback Loops in the p53 Network That Control the Cellular Response to DNA Damage By Minsoo Choi, Jue Shi, Sung Hoon Jung, Xi Chen, Kwang-Hyun Cho Science Signaling20 Nov 2012 : ra83 State-space analysis of the p53 network identifies a therapeutic strategy for treating cancer. Supplementary Materials