Contents
Vol 5, Issue 252
Contents
Research Articles
- Regulation of Phosphatidylinositol-5-Phosphate Signaling by Pin1 Determines Sensitivity to Oxidative Stress
Increasing the abundance of the phospholipid PtdIns5P protects cells from oxidative stress.
- Lack of the Phosphatase PTPN22 Increases Adhesion of Murine Regulatory T Cells to Improve Their Immunosuppressive Function
Loss of the phosphatase PTPN22 enhances the functions of both effector and regulatory T cells.
Perspective
- Remodeling a Tissue: Subtraction Adds Insight
Imaging, modeling, and genetics reveal the roles of an atypical myosin in morphogenesis.
Podcast
- Science Signaling Podcast: 27 November 2012
A phosphatase implicated in autoiummunity modulates the activities of both effector and regulatory T cells.
Editors' Choice
- Ceramide Keeps Mast Cells in Check
A receptor that binds to extracellular ceramide inhibits mast cell activation and allergic responses in vivo.
- The Allergen in the Dust
The bacterial protein flagellin can promote allergic asthma by activating Toll-like receptor 5.
- Double Delivery During Plant Fertilization
The cysteine-rich proteins of Arabidopsis egg and central cells enable fusion with just one sperm each.
- Bcl10 Does Double Duty
A protein that promotes NF-κB signaling during the immune response is also required for phagocytosis independently of NF-κB.
- Help for Starving Cells
A metabolite is identified that may help cancer cells coordinate their mode of energy generation with nutrient conditions.
Erratum
- A Correction to the Presentation Titled: “Protein Complexes and Target Genes Identification by in Vivo Biotinylation: The STAT5 Paradigm” by E. Katsantoni
A typographical error in the name of a medical condition described on Slide 9 is corrected.
