Contents
Vol 5, Issue 253
Contents
Research Articles
- RNF4-Dependent Hybrid SUMO-Ubiquitin Chains Are Signals for RAP80 and Thereby Mediate the Recruitment of BRCA1 to Sites of DNA Damage
DNA repair proteins find sites of damage marked by hybrid SUMO-ubiquitin chains.
- G Protein–Coupled Receptor–Mediated Activation of p110β by Gβγ Is Required for Cellular Transformation and Invasiveness
Blocking the activation of p110β by G proteins inhibits tumor cell proliferation.
Perspective
- Cdc42 Oscillations in Yeasts
Oscillations in the localization of active Cdc42 govern polarized cell growth in yeasts.
Presentation
- SCF-Mediated Degradation of p100 (NF-κB2): Mechanisms and Relevance in Multiple Myeloma
Ubiquitin-mediated degradation of an inhibitor of noncanonical NF-κB signaling promotes cell survival.
Editors' Choice
- Antigenic Vitamins
Specific forms of vitamin B produced by microbes are recognized by the antigen-presenting receptor MR1 and activate the immune response in the gut.
- Estrogen Represses Liver Tumors
Estrogen signaling suppresses the growth of hepatocellular carcinoma by preventing alternative activation of tumor-associated macrophages.
- A Common Mediator of Resistance
MED12 inhibits TGF-β signaling through a nontranscriptional mechanism.
- Oct4 Connects Akt to Cancerous Stem Cells
Akt promotes its own expression, cell survival, and tumorigenicity in embryonal carcinoma cells by phosphorylating Oct4.
- Switching from Shh-Mediated Attraction to Repulsion
An increase in 14-3-3 proteins switches axons from being attracted to being repulsed by Sonic hedgehog.
- Notch Ligand Discrimination
An EGF repeat in the extracellular domain of Notch allows this receptor to discriminate between ligands.
- Imprinting Evolution
Parental genetic conflict may have exploited changes in the coding of a protein loop in a growth factor receptor.
