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vol. 5 no. 253 ra88
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- Received August 10, 2012
- Accepted November 8, 2012
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Copyright © 2012, American Association for the Advancement of Science
Research ArticleDNA damage
RNF4-Dependent Hybrid SUMO-Ubiquitin Chains Are Signals for RAP80 and Thereby Mediate the Recruitment of BRCA1 to Sites of DNA Damage
- Catherine M. Guzzo1,
- Christopher E. Berndsen2,*,
- Jianmei Zhu1,
- Vibhor Gupta3,
- Ajit Datta2,†,
- Roger A. Greenberg3,
- Cynthia Wolberger2, and
- Michael J. Matunis1,‡
- 1Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.
- 2Department of Biophysics and Biophysical Chemistry and the Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
- 3Department of Cancer Biology and Department of Pathology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
- ↵‡To whom correspondence should be addressed. E-mail: mmatunis{at}jhsph.edu
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Science Signaling 04 Dec 2012:
Vol. 5, Issue 253, pp. ra88
DOI: 10.1126/scisignal.2003485
Vol. 5, Issue 253, pp. ra88
DOI: 10.1126/scisignal.2003485
Catherine M. Guzzo
1Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Christopher E. Berndsen
2Department of Biophysics and Biophysical Chemistry and the Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Jianmei Zhu
1Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Vibhor Gupta
3Department of Cancer Biology and Department of Pathology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ajit Datta
2Department of Biophysics and Biophysical Chemistry and the Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Roger A. Greenberg
3Department of Cancer Biology and Department of Pathology, Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Cynthia Wolberger
2Department of Biophysics and Biophysical Chemistry and the Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Michael J. Matunis
1Department of Biochemistry and Molecular Biology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.
